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使用改良版婴幼儿孤独症检查表修订版(M-CHAT-R/F)进行早期孤独症筛查的性别差异。

Sex differences in early autism screening using the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F).

机构信息

Drexel University, USA.

Kennedy Krieger Institute & Johns Hopkins School of Medicine, USA.

出版信息

Autism. 2023 Oct;27(7):2112-2123. doi: 10.1177/13623613231154728. Epub 2023 Feb 14.

DOI:10.1177/13623613231154728
PMID:36786236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10423742/
Abstract

This study examined a widely used autism screening tool, the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up to identify differences in screening for autism between toddler males and females. Examining sex differences in screening for autism in toddlerhood is important as it determines who will be referred for evaluations and receive diagnoses, which is critical for access to autism-specific early intervention. This study found that females were less likely to screen positive and be invited for evaluations compared with males. Females at high likelihood for autism were less likely to be diagnosed with autism, which decreases confidence in the screener's results. Importantly, the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up accurately identified both males and females with autism. Future research should examine ways to improve accuracy in screening results for females.

摘要

本研究考察了一种广泛使用的自闭症筛查工具——改良婴幼儿自闭症检查表修订版及随访版,以确定男童和女童自闭症筛查之间的差异。在婴幼儿期筛查自闭症时,研究性别差异很重要,因为这决定了谁将被推荐进行评估并接受诊断,这对获得自闭症特定的早期干预至关重要。本研究发现,与男童相比,女童筛查阳性并被邀请进行评估的可能性较小。自闭症高风险的女童被诊断为自闭症的可能性较低,这降低了对筛查结果的信心。重要的是,改良婴幼儿自闭症检查表修订版及随访版准确地识别出了自闭症男童和女童。未来的研究应探讨如何提高女性筛查结果的准确性。

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本文引用的文献

1
Sensitivity and Specificity of the Modified Checklist for Autism in Toddlers (Original and Revised): A Systematic Review and Meta-analysis.改良版婴幼儿自闭症检查表(原始版和修订版)的敏感性和特异性:系统评价和荟萃分析。
JAMA Pediatr. 2023 Apr 1;177(4):373-383. doi: 10.1001/jamapediatrics.2022.5975.
2
Validation of the Electronic Modified Checklist for Autism in Toddlers, Revised with Follow-Up: A Nonrandomized Controlled Trial.电子改良版孤独症幼儿检查表修订版(含随访)的验证:一项非随机对照试验。
J Pediatr. 2023 Nov;262:113343. doi: 10.1016/j.jpeds.2022.11.044. Epub 2023 Feb 2.
3
Exclusion of females in autism research: Empirical evidence for a "leaky" recruitment-to-research pipeline.自闭症研究中对女性的排除:“渗漏”的招募-研究管道的实证证据。
Autism Res. 2022 Oct;15(10):1929-1940. doi: 10.1002/aur.2795. Epub 2022 Aug 22.
4
Analysis of Race and Sex Bias in the Autism Diagnostic Observation Schedule (ADOS-2).自闭症诊断观察量表(ADOS-2)中的种族和性别偏见分析。
JAMA Netw Open. 2022 Apr 1;5(4):e229498. doi: 10.1001/jamanetworkopen.2022.9498.
5
Sex Differences in Autism: Examining Intrinsic and Extrinsic Factors in Children and Adolescents Enrolled in a National ASD Cohort.自闭症的性别差异:在全国自闭症队列中对儿童和青少年的内在和外在因素进行研究。
J Autism Dev Disord. 2023 Apr;53(4):1305-1318. doi: 10.1007/s10803-021-05385-y. Epub 2021 Dec 2.
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Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018.4 岁儿童自闭症谱系障碍的早期识别 - 自闭症和发育障碍监测网络,美国 11 个地点,2018 年。
MMWR Surveill Summ. 2021 Dec 3;70(10):1-14. doi: 10.15585/mmwr.ss7010a1.
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Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018.8 岁儿童自闭症谱系障碍的流行率和特征 - 自闭症和发育障碍监测网络,美国 11 个地点,2018 年。
MMWR Surveill Summ. 2021 Dec 3;70(11):1-16. doi: 10.15585/mmwr.ss7011a1.
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The Toddler Autism Symptom Inventory: Use in diagnostic evaluations of toddlers.《幼儿自闭症症状量表》:在幼儿诊断评估中的应用。
Autism. 2021 Nov;25(8):2386-2399. doi: 10.1177/13623613211021699. Epub 2021 Jun 15.
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Connecting the Dots: a cluster-randomized clinical trial integrating standardized autism spectrum disorders screening, high-quality treatment, and long-term outcomes.连接各个环节:一项整群随机临床试验,整合了标准化的自闭症谱系障碍筛查、高质量治疗及长期预后。
Trials. 2021 May 2;22(1):319. doi: 10.1186/s13063-021-05286-6.
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Early and Repeated Screening Detects Autism Spectrum Disorder.早期和重复筛查可发现自闭症谱系障碍。
J Pediatr. 2021 Jul;234:227-235. doi: 10.1016/j.jpeds.2021.03.009. Epub 2021 Mar 10.