Clarke M, Gill J, Noronha M, McKinlay I
Children's Hospital, Blackley, Manchester.
Dev Med Child Neurol. 1987 Aug;29(4):520-8. doi: 10.1111/j.1469-8749.1987.tb02512.x.
Eleven infants with neonatal onset of intractable epilepsy are described, who showed the clinical and electroencephalographic features of Ohtahara syndrome. With time, transition to West and Lennox-Gastaut syndromes occurred. No cause could be found in eight cases. All nine survivors are severely mentally and physically handicapped and continue to have seizures. Early infantile epileptic encephalopathy represents the earliest of the age-dependent epileptic encephalopathies.
本文描述了11例新生儿期起病的难治性癫痫婴儿，他们表现出大田原综合征的临床和脑电图特征。随着时间推移，病情转变为West综合征和Lennox-Gastaut综合征。8例未发现病因。所有9名幸存者均有严重的智力和身体残疾，且仍有癫痫发作。早期婴儿癫痫性脑病是年龄依赖性癫痫性脑病中最早出现的类型。
