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1-[ω-(溴苯氧基)烷基]-3-萘甲基尿嘧啶衍生物及其类似物的合成作为人巨细胞病毒复制的可能抑制剂。

Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication.

机构信息

Volgograd State Medical University, Volgograd, Russia.

Rega Institute for Medical Research, B-3000, Leuven, KU Leuven, Belgium.

出版信息

Dokl Biochem Biophys. 2022 Dec;507(1):357-362. doi: 10.1134/S1607672922340099. Epub 2023 Feb 14.

DOI:10.1134/S1607672922340099
PMID:36787002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9926436/
Abstract

A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing naphthalen-1-yl, naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene-9-ylmethyl fragments in position 3 of uracil residue was synthesized. The antiviral properties of the synthesized compounds against human cytomegalovirus were studied. It was found that the compound containing a bridge consisting of five methylene groups exhibits a high anti-cytomegalovirus activity in vitro.

摘要

合成了一系列含有萘-1-基、萘-2-基、1-溴-2-萘甲基、苄基和蒽-9-基甲基片段的 1-[ω-(溴苯氧基)烷基]-尿嘧啶衍生物。研究了合成化合物对人巨细胞病毒的抗病毒特性。结果发现，含有由五个亚甲基组成的桥的化合物在体外具有很高的抗巨细胞病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/3acc5da89f38/10628_2023_7362_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/4a72772a0910/10628_2023_7362_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/86edc6db0082/10628_2023_7362_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/37de79fc8ac0/10628_2023_7362_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/3acc5da89f38/10628_2023_7362_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/4a72772a0910/10628_2023_7362_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/86edc6db0082/10628_2023_7362_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/37de79fc8ac0/10628_2023_7362_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/9926436/3acc5da89f38/10628_2023_7362_Fig4_HTML.jpg

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Intervirology. 2020;63(1-6):10-16. doi: 10.1159/000506683. Epub 2020 Aug 7.
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Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC).
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Microorganisms. 2020 Jul 20;8(7):1078. doi: 10.3390/microorganisms8071078.
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