1-取代的3-[ω-(4-氧代喹唑啉-4(3H)-基)烷基]尿嘧啶衍生物的合成及抗病毒特性
Synthesis and Antiviral Properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4(3H)-yl)alkyl]uracil Derivatives.
作者信息
Paramonova M P, Khandazhinskaya A L, Ozerov A A, Kochetkov S N, Snoeck R, Andrei G, Novikov M S
机构信息
Department of Pharmaceutical & Toxicological Chemistry, Volgograd State Medical University, Volgograd, 400131 Russia.
Engelhardt Institute of Molecular Biology, Russian Academy of Science, Moscow, 119991 Russia.
出版信息
Acta Naturae. 2020 Jul-Sep;12(3):134-139. doi: 10.32607/actanaturae.10983.
A series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for new antiviral agents. Some compounds in this series are shown to exhibit high inhibitory activity against human cytomegalovirus and the varicella zoster virus in a HEL cell culture.
合成了一系列尿嘧啶衍生物，这些衍生物含有通过短亚甲基桥与嘧啶环的氮原子N3相连的4-氧代喹唑啉片段，以寻找新型抗病毒剂。该系列中的一些化合物在HEL细胞培养中显示出对人巨细胞病毒和水痘带状疱疹病毒的高抑制活性。
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