巨细胞病毒感染是胃肠道癌症的一个危险因素：一项横断面和荟萃分析研究。

Cytomegalovirus Infection Is a Risk Factor in Gastrointestinal Cancer: A Cross-Sectional and Meta-Analysis Study.

机构信息

Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China,

出版信息

Intervirology. 2020;63(1-6):10-16. doi: 10.1159/000506683. Epub 2020 Aug 7.

DOI:10.1159/000506683

PMID:32772018

Abstract

BACKGROUND

This study was planned to investigate the association betweenhuman cytomegalovirus (HCMV) infection and gastrointestinal cancer (GIC) risk, by undertaking a meta-analysis and case-control cross-sectional study.

SUMMARY

A cross-sectional study analysis of 160 GIC patients and 100 control subjects indicated significantly higher HCMV prevalence in GIC patients based on the HCMV IgM test. However, a similar analysis based on an IgG test revealed no significant relationship. Further meta-analysis of 11 studies, including 1,044 patients and 991 healthy subjects, displayed HCMV infection as an important risk factor for not only colorectal cancer occurrence and development based on a HCMV DNA test, but also for GIC based on a HCMV IgM test. However, the IgG test again displayed no significant relationship between HCMV infection and GIC occurrence. Key Message: Overall, our study revealed that HCMV infection is associated with an increased GIC risk. However, additional studies are warranted to elucidate the molecular mechanism underlying this association.

摘要

背景

本研究通过荟萃分析和病例对照横断面研究，旨在探讨人巨细胞病毒（HCMV）感染与胃肠道癌（GIC）风险之间的关系。

总结

对 160 例 GIC 患者和 100 例对照者进行的横断面研究分析表明，基于 HCMV IgM 检测，GIC 患者的 HCMV 患病率显著更高。然而，基于 IgG 检测的类似分析并未显示出显著的相关性。进一步对包括 11 项研究在内的 1044 例患者和 991 例健康受试者进行的荟萃分析显示，HCMV 感染不仅是结直肠癌发生和发展的重要危险因素（基于 HCMV DNA 检测），也是 GIC 的重要危险因素（基于 HCMV IgM 检测）。然而，IgG 检测再次显示 HCMV 感染与 GIC 发生之间无显著相关性。