Ma Wenbin, Regenthal Ralf, Krügel Ute
School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Division of Clinical Pharmacology, Rudolf Boehm Institute for Pharmacology and Toxicology, Leipzig University, 04107 Leipzig, Germany.
Nutrients. 2025 Jul 21;17(14):2383. doi: 10.3390/nu17142383.
: Mental health and healthy eating are inextricably linked by bi-directional interaction. As pharmacological interventions for eating disorders and mental illness have limited efficacy and are associated with significant side effects, natural compounds traditionally used in these fields represent an extremely rich source for potential future drugs. This review aims to summarise complex and/or specific pharmacological and clinical effects of mixed compositions and individual compounds derived from , , and as well as from and other berberine (BBR)-containing plants, which have been traditionally used for eating and mental health purposes. The data on favoured natural compounds and main ingredients of compound mixtures presented here could provide new impetus for preventive or targeted supplementary treatment, potential drug development, and the design of new compound congeners with improved target spectrum and potency in mental health disorders and eating-related issues. Contemporary methodological development steps in this direction are then proposed.
心理健康与健康饮食通过双向相互作用紧密相连。由于饮食失调和精神疾病的药物干预疗效有限且伴有显著副作用，传统上在这些领域使用的天然化合物是未来潜在药物的极其丰富的来源。本综述旨在总结从、和以及从和其他含小檗碱（BBR）植物中提取的混合成分和单个化合物的复杂和/或特定药理及临床作用，这些植物传统上用于饮食和心理健康目的。此处呈现的关于受青睐的天然化合物和化合物混合物主要成分的数据可为预防或靶向补充治疗、潜在药物开发以及设计具有改善的靶点谱和效力的新型化合物同系物提供新的动力，以应对心理健康障碍和饮食相关问题。然后提出了朝着这个方向的当代方法学发展步骤。
