关注声明：喹啉酸与晚期糖基化终产物受体（RAGE）相互作用的建模：与早期神经病理过程的相关性 - Suppr

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Expression of Concern: Modeling the Interaction between Quinolinate and the Receptor for Advanced Glycation End Products (RAGE): Relevance for Early Neuropathological Processes.

出版信息

PLoS One. 2023 Feb 14;18(2):e0281905. doi: 10.1371/journal.pone.0281905. eCollection 2023.

DOI:10.1371/journal.pone.0281905

PMID:36787334

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9928092/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc53/9928092/8d345a233302/pone.0281905.g001.jpg

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Expression of Concern: Modeling the Interaction between Quinolinate and the Receptor for Advanced Glycation End Products (RAGE): Relevance for Early Neuropathological Processes.关注声明：喹啉酸与晚期糖基化终产物受体（RAGE）相互作用的建模：与早期神经病理过程的相关性

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S-Allylcysteine Protects Against Excitotoxic Damage in Rat Cortical Slices Via Reduction of Oxidative Damage, Activation of Nrf2/ARE Binding, and BDNF Preservation.S-烯丙半胱氨酸通过减少氧化损伤、激活 Nrf2/ARE 结合和保护 BDNF 来防止大鼠皮质切片的兴奋毒性损伤。

Neurotox Res. 2020 Dec;38(4):929-940. doi: 10.1007/s12640-020-00260-7. Epub 2020 Aug 19.

Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms.3-甲基戊二酸扰乱大鼠脑突触体线粒体功能并诱导氧化应激的实验证据：新的趋同机制

Neurochem Res. 2016 Oct;41(10):2619-2626. doi: 10.1007/s11064-016-1973-2. Epub 2016 Jun 9.

Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias.喹啉酸与戊二酸血症I型及大鼠脑突触体中丙酸代谢紊乱时积累的有机酸之间的毒性协同作用：与代谢性酸中毒的相关性

Neuroscience. 2015 Nov 12;308:64-74. doi: 10.1016/j.neuroscience.2015.09.002. Epub 2015 Sep 4.

PLoS One. 2015 Mar 10;10(3):e0120221. doi: 10.1371/journal.pone.0120221. eCollection 2015.

Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway.通过犬尿氨酸途径的毒性代谢产物喹啉酸，早期调节啮齿动物纹状体切片中的转录因子 Nrf2。

Neuroscience. 2014 Feb 28;260:130-9. doi: 10.1016/j.neuroscience.2013.12.025. Epub 2013 Dec 19.

Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine.抗氧化策略挽救神经毒模型大鼠突触体的氧化损伤和能量衰竭：S-烯丙半胱氨酸的保护作用。

J Neural Transm (Vienna). 2010 Jan;117(1):35-44. doi: 10.1007/s00702-009-0299-5. Epub 2009 Oct 29.

Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington's disease.针对氧化/氮能应激可改善运动障碍，并减轻亨廷顿舞蹈症两种模型中的突触线粒体功能障碍和脂质过氧化。

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Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats.细胞质钙在大鼠兴奋性毒性/能量缺乏协同模型中介导氧化损伤。

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