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Differences in the immunogenicity of engineered circular RNAs.

作者信息

Tai Justin, Chen Y Grace

机构信息

Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

出版信息

J Mol Cell Biol. 2023 Jun 1;15(1). doi: 10.1093/jmcb/mjad002.

Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8da0/10257478/112c7bab3c2e/mjad002fig1.jpg

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circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation.
Adv Sci (Weinh). 2022 Mar;9(8):e2103817. doi: 10.1002/advs.202103817. Epub 2022 Jan 24.
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RNA circles with minimized immunogenicity as potent PKR inhibitors.
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N6-Methyladenosine Modification Controls Circular RNA Immunity.
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Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.
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RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo.
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Engineering circular RNA for potent and stable translation in eukaryotic cells.
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A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity. 2018 Apr 17;48(4):688-701.e7. doi: 10.1016/j.immuni.2018.03.016. Epub 2018 Apr 3.
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