人类转铁蛋白基因的完整结构。与类似的鸡基因和人类假基因的比较。

Complete structure of the human transferrin gene. Comparison with analogous chicken gene and human pseudogene.

作者信息

Schaeffer E, Lucero M A, Jeltsch J M, Py M C, Levin M J, Chambon P, Cohen G N, Zakin M M

机构信息

Unité de Biochimie Cellulaire, Institut Pasteur, Paris, France.

出版信息

Gene. 1987;56(1):109-16. doi: 10.1016/0378-1119(87)90163-6.

DOI:10.1016/0378-1119(87)90163-6

PMID:3678832

Abstract

The complete structure of the human transferrin gene is presented. This gene has a total size of about 33.5 kb and is organized in 17 exons separated by 16 introns. The chicken ovotransferrin gene has a size of 10.5 kb and is also organized in 17 exons and 16 introns. The analysis of the structure of the two genes confirm, at the gene level, that transferrins originated by a gene duplication phenomenon. Finally, the existence of a new member of the transferrin family, a human transferrin non-processed pseudogene is demonstrated.

摘要

本文展示了人类转铁蛋白基因的完整结构。该基因全长约33.5kb，由17个外显子和16个内含子组成。鸡卵转铁蛋白基因大小为10.5kb，同样由17个外显子和16个内含子组成。对这两个基因结构的分析在基因层面证实，转铁蛋白起源于基因复制现象。最后，证明了转铁蛋白家族的一个新成员——人类未加工的转铁蛋白假基因的存在。