长链非编码 RNA 介导的内皮细胞调控：冠状动脉粥样硬化性疾病发病机制的新进展。
LncRNA-mediated Modulation of Endothelial Cells: Novel Progress in the Pathogenesis of Coronary Atherosclerotic Disease.
机构信息
Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang 421001, China.
Key Laboratory of Heart Failure Prevention & Treatment of Hengyang, Department of Cardiovascular Medicine, Hengyang Medical School, The Second Affiliated Hospital, Clinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, University of South China, Hunan 421001, China.
出版信息
Curr Med Chem. 2024;31(10):1251-1264. doi: 10.2174/0929867330666230213100732.
Coronary atherosclerotic disease (CAD) is a common cardiovascular disease and an important cause of death. Moreover, endothelial cells (ECs) injury is an early pathophysiological feature of CAD, and long noncoding RNAs (lncRNAs) can modulate gene expression. Recent studies have shown that lncRNAs are involved in the pathogenesis of CAD, especially by regulating ECs. In this review, we summarize the novel progress of lncRNA-modulated ECs in the pathogenesis of CAD, including ECs proliferation, migration, adhesion, angiogenesis, inflammation, apoptosis, autophagy, and pyroptosis. Thus, as lncRNAs regulate ECs in CAD, lncRNAs will provide ideal and novel targets for the diagnosis and drug therapy of CAD.
冠状动脉粥样硬化性疾病（CAD）是一种常见的心血管疾病，也是死亡的重要原因。此外，内皮细胞（ECs）损伤是 CAD 的早期病理生理学特征，而长链非编码 RNA（lncRNAs）可以调节基因表达。最近的研究表明，lncRNAs 参与了 CAD 的发病机制，特别是通过调节 ECs。在这篇综述中，我们总结了 lncRNA 调节 CAD 发病机制中 ECs 的新进展，包括 ECs 的增殖、迁移、黏附、血管生成、炎症、细胞凋亡、自噬和细胞焦亡。因此，由于 lncRNAs 在 CAD 中调节 ECs，lncRNAs 将为 CAD 的诊断和药物治疗提供理想和新颖的靶点。
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