Diao He, Lu Yunhua, Ling Yun, Shen Yingjie, Yu Jingmou, Ma Kun
School of Life Science and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China.
Huzhou Key Laboratory of Medical and Environmental Applications Technologies, School of Life Sciences, Huzhou University, Huzhou, 313000, China.
Curr Pharm Des. 2023;29(9):640-651. doi: 10.2174/1381612829666230213152259.
The self-assembly of peptides is very popular in biomedical fields. Peptide-based assemblies have been used as an ideal candidate for drug/gene delivery, tissue engineering, and antibacterial/anticancer agents. The morphology and structure of peptide self-assembly can be changed by altering the molecular structure and the self-assembly conditions. Engineering peptide assemblies present great potential in medical fields. In this review, the structure and function of peptide self-assembly have been described. Also, the advances in peptide- based self-assembly have been highlighted in biomedical applications, such as drug packaging and delivery, tissue engineering, antibacterial agents, siRNA-targeted delivery and vaccines. Moreover, the challenges and future perspectives of the self-assembly of polypeptides are discussed.
肽的自组装在生物医学领域非常普遍。基于肽的组装体已被用作药物/基因递送、组织工程以及抗菌/抗癌剂的理想候选物。通过改变分子结构和自组装条件，可以改变肽自组装的形态和结构。工程化肽组装体在医学领域具有巨大潜力。在本综述中，描述了肽自组装的结构和功能。此外，还重点介绍了基于肽的自组装在生物医学应用中的进展，如药物包装与递送、组织工程、抗菌剂、siRNA靶向递送和疫苗。此外，还讨论了多肽自组装面临的挑战和未来前景。
