Bhandarkar Vidit, Dinter Teresa, Spranger Stefani
Koch Institute at MIT, Cambridge, MA 02139, USA.
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Sci Immunol. 2025 Jan 17;10(103):eadf4726. doi: 10.1126/sciimmunol.adf4726.
Immune responses against cancer are dominated by T cell exhaustion and dysfunction. Recent advances have underscored the critical role of early priming interactions in establishing T cell fates. In this review, we explore the importance of dendritic cell (DC) signals in specifying CD8 T cell fates in cancer, drawing on insights from acute and chronic viral infection models. We highlight the role of DCs in lymph nodes and tumors in maintaining stem-like CD8 T cells, which are critical for durable antitumor immune responses. Understanding how CD8 T cell fates are determined will enable the rational design of immunotherapies, particularly therapeutic cancer vaccines, that can modulate DC-T cell interactions to generate beneficial CD8 T cell fates.
针对癌症的免疫反应主要由T细胞耗竭和功能障碍主导。最近的进展凸显了早期启动相互作用在确定T细胞命运中的关键作用。在这篇综述中，我们借鉴急性和慢性病毒感染模型的见解，探讨树突状细胞（DC）信号在确定癌症中CD8 T细胞命运方面的重要性。我们强调DC在淋巴结和肿瘤中维持干细胞样CD8 T细胞的作用，这对于持久的抗肿瘤免疫反应至关重要。了解CD8 T细胞命运是如何确定的，将有助于合理设计免疫疗法，特别是治疗性癌症疫苗，其可以调节DC-T细胞相互作用以产生有益的CD8 T细胞命运。
