Department of Plastic Surgery, Lanzhou University Second Hospital, Lanzhou, China.
Department of Ophthalmology, Jiading Central Hospital University of Medicine & Health Sciences, Shanghai, China.
Int Wound J. 2023 Aug;20(6):2473-2481. doi: 10.1111/iwj.14102. Epub 2023 Feb 14.
Ferroptosis is a newly discovered cell death type which is different from apoptosis, autophagy, pyroptosis as well as necrosis in the following aspects: morphology, biochemistry, gene and regulatory mechanisms. Ferroptosis is regulated by multiples of mechanisms such as system Xc mechanism, glutathione peroxidase 4 (GPX4) mechanism, iron metabolism and lipid metabolism. Currently, ferroptosis has been revealed to be significant in wound healing such as diabetic wound, irradiated wound and ultraviolet (UV)-driven wound. Hence, how to intervene in the pathogenesis as well as the development of wounds and promote the wound healing by the regulation of ferroptosis have become a research hotspot. This review systematically summarises the latest scientific advances of ferroptosis and wound healing fields, with hoping to propose a new insight and advance in the wound treatment.
铁死亡是一种新发现的细胞死亡方式，与细胞凋亡、自噬、细胞焦亡和坏死在形态学、生物化学、基因和调控机制等方面均有所不同。铁死亡受多种机制调控，如系统 Xc 机制、谷胱甘肽过氧化物酶 4（GPX4）机制、铁代谢和脂质代谢等。目前，铁死亡在糖尿病创面、放射性创面和紫外线（UV）驱动的创面等创面愈合中已被证实具有重要作用。因此，如何通过调控铁死亡来干预创面的发病机制和发展，并促进创面愈合，已成为研究热点。本综述系统总结了铁死亡和创面愈合领域的最新科学进展，希望为创面治疗提供新的思路和进展。
