Tan Xin, Huang Xiang, Niu Baolong, Guo Xingdong, Lei Xiao, Qu Baolin
Department of Radiation Oncology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Medical School of Chinese PLA, Beijing, China.
Front Mol Biosci. 2022 Dec 16;9:1102158. doi: 10.3389/fmolb.2022.1102158. eCollection 2022.
Radiotherapy is applied in about 70% patients with tumors, yet radioresistance of tumor cells remains a challenge that limits the efficacy of radiotherapy. Ferroptosis, an iron-dependent lipid peroxidation regulated cell death, is involved in the development of a variety of tumors. Interestingly, there is evidence that ferroptosis inducers in tumor treatment can significantly improve radiotherapy sensitivity. In addition, related studies show that Glutathione S-transferase P1 (GSTP1) is closely related to the development of ferroptosis. The potential mechanism of targeting GSTP1 to inhibit tumor cells from evading ferroptosis leading to radioresistance has been proposed in this review, which implies that GSTP1 may play a key role in radiosensitization of lung cancer ferroptosis pathway.
约70%的肿瘤患者会接受放射治疗，但肿瘤细胞的放射抗性仍然是一个限制放射治疗疗效的挑战。铁死亡是一种铁依赖性脂质过氧化调节的细胞死亡，参与多种肿瘤的发生发展。有趣的是，有证据表明肿瘤治疗中的铁死亡诱导剂可显著提高放射敏感性。此外，相关研究表明谷胱甘肽S-转移酶P1（GSTP1）与铁死亡的发生密切相关。本综述提出了靶向GSTP1抑制肿瘤细胞逃避铁死亡导致放射抗性的潜在机制，这意味着GSTP1可能在肺癌铁死亡途径的放射增敏中起关键作用。
