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用紫杉醇治疗的免疫功能正常患者的卡波西肉瘤

Kaposi Sarcoma in an Immunocompetent Patient Treated With Paclitaxel.

作者信息

Sharma Sunakshi, Malgotra Vikas, Wani Mashkoor

机构信息

Dermatology, Government Medical College, Jammu, IND.

Dermatology, Rama Medical College, Hapur, IND.

出版信息

Cureus. 2023 Jan 11;15(1):e33641. doi: 10.7759/cureus.33641. eCollection 2023 Jan.

DOI:10.7759/cureus.33641
PMID:36788873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9918335/
Abstract

Kaposi sarcoma (KS) is a rare multifocal tumor originating from the cells lining the blood vessels. It is characterized by vascular proliferation and is usually associated with immunosuppression due to multiple factors, including AIDS or organ transplantation. However, sporadic cases of KS have been reported in HIV-negative immunocompetent patients. Paclitaxel has shown efficacy and may be an alternative for the initial therapy of patients with KS. We report a case of KS in a 70-year-old Asian male who was HIV-negative, with no history of immunosuppression or homosexuality and a good response to treatment with Paclitaxel.

摘要

卡波西肉瘤(KS)是一种罕见的多灶性肿瘤,起源于血管内衬细胞。其特征为血管增生,通常因多种因素导致免疫抑制而发生,这些因素包括艾滋病或器官移植。然而,在HIV阴性的免疫功能正常患者中也有散发性KS病例的报道。紫杉醇已显示出疗效,可能是KS患者初始治疗的一种选择。我们报告一例70岁亚洲男性的KS病例,该患者HIV阴性,无免疫抑制或同性恋史,对紫杉醇治疗反应良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c718/9918335/10423a91e006/cureus-0015-00000033641-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c718/9918335/10423a91e006/cureus-0015-00000033641-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c718/9918335/10423a91e006/cureus-0015-00000033641-i01.jpg

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本文引用的文献

1
A case of classic Kaposi sarcoma in an immunocompetent human immunodeficiency virus-negative Dominican man.一名免疫功能正常、人类免疫缺陷病毒阴性的多米尼加男子患经典型卡波西肉瘤的病例。
SAGE Open Med Case Rep. 2020 Jul 2;8:2050313X20938249. doi: 10.1177/2050313X20938249. eCollection 2020.
2
Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC).卡波西肉瘤的诊断和治疗:基于欧洲共识的跨学科指南(EDF/EADO/EORTC)。
Eur J Cancer. 2019 Jun;114:117-127. doi: 10.1016/j.ejca.2018.12.036. Epub 2019 May 13.
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卡波西肉瘤的流行病学:回顾与非流行型变体的描述。
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Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran.伊朗人类疱疹病毒 8 (HHV-8)的血清流行率和卡波西肉瘤的发病率。
Infect Agent Cancer. 2011 Apr 28;6:5. doi: 10.1186/1750-9378-6-5.