Gupta Kush, Tun Aung, Gupta Ashish, Berkowitz Leonard B, Anwar Raheel, Liu Yingxian, Guevara Elizabeth
Kasturba Medical College, Mangalore, Karnataka, India.
Hematology Oncology, The Brooklyn Hospital Center, New York, NY, USA.
SAGE Open Med Case Rep. 2020 Jul 2;8:2050313X20938249. doi: 10.1177/2050313X20938249. eCollection 2020.
Kaposi sarcoma is an uncommon tumor that primarily arises in the skin and mucosal surfaces, but may metastasize to the internal organs. Four main variants of Kaposi sarcoma are recognized as the following: classic Kaposi sarcoma, which occurs in middle-aged or elderly men; epidemic Kaposi sarcoma, associated with human immunodeficiency virus infection; iatrogenic Kaposi sarcoma seen in patients on immunosuppressive drug therapy; and endemic Kaposi sarcoma. This report is of a case of classic Kaposi sarcoma in 55-year-old immunocompetent and human immunodeficiency virus-negative Dominican man who had lived in the United States for 2 years, who presented with a 2-year history of skin lesions on his lower extremities and soft palate. Biopsy of the soft palate was consistent with Kaposi sarcoma. The patient was treated with paclitaxel with a good response. This case report demonstrates the importance of recognizing that classic Kaposi sarcoma, first described almost 150 years ago, can still present in immunocompetent middle-aged men of all ethnicities.
卡波西肉瘤是一种罕见的肿瘤，主要发生于皮肤和黏膜表面，但也可能转移至内脏器官。卡波西肉瘤主要有以下四种类型：经典型卡波西肉瘤，发生于中年或老年男性；流行型卡波西肉瘤，与人类免疫缺陷病毒感染有关；医源性卡波西肉瘤，见于接受免疫抑制药物治疗的患者；以及地方性卡波西肉瘤。本报告介绍了一例经典型卡波西肉瘤病例，患者为一名55岁免疫功能正常且人类免疫缺陷病毒阴性的多米尼加男性，在美国生活了2年，有下肢和软腭皮肤病变2年的病史。软腭活检结果符合卡波西肉瘤。该患者接受紫杉醇治疗，反应良好。本病例报告表明，认识到近150年前首次描述的经典型卡波西肉瘤仍可出现在所有种族免疫功能正常的中年男性中非常重要。
