Onuk Sevda, Sipahioglu Hilal, Beştepe Dursun Zehra, Eren Esma, Aslan Sırakaya Hatice, Kuzugüden Sibel, Celik Ilhami
Department of Intensive Care Unit, Kayseri City Education and Research Hospital, Kayseri, TUR.
Department of Clinical Microbiology and Infectious Diseases, Kayseri City Education and Research Hospital, Kayseri, TUR.
Cureus. 2023 Feb 11;15(2):e34882. doi: 10.7759/cureus.34882. eCollection 2023 Feb.
Background This study aimed to investigate the effects of serum high mobility group box-1 (HMGB1), interleukin (IL)-6, IL-8, IL-1β, IL-10, and tumor necrosis factor alpha (TNF-α) levels on disease severity and mortality in Crimean-Congo hemorrhagic fever (CCHF) patients. Materials and methods This study was performed prospectively in the intensive care unit (ICU) and infection ward of a tertiary hospital in the Republic of Türkiye. Patients aged 18 years and older diagnosed with CCHF were included. Results Our study included 30 patients, of whom 83.3% were male, where the mean age was 51.6±14.35 years. The most common clinical findings in patients were malaise (90%) and myalgia (63.3%). In our study, IL-1β levels were found to be 1173.6 (783.0-1823.0) pg/mL, IL-6 69.9 (56.8-133.1) pg/mL, IL-8 191.2 (152.8-516.9) pg/mL, TNF-α 129.5 (104.9-270.8), HMGB1 37.01 (29.26-75.18), and IL-10 190.1 (IQR: 147.8-387.8) pg/mL. The patients' median Severity Scoring Index (SSI) score was found to be 2.5 (1.8-5.5). There was a moderate correlation between the patients' SSI score and serum IL-6 (r=0.464, p=0.010), TNF-α (r=0.420, p=0.021), and IL-10 levels (r=0.518, p=0.003), and a weak correlation between serum HMGB1 (r=0.392, p=0.032). The correlation between SSI and creatine phosphokinase (CPK) levels (r=0.499, p=0.036) was observed to be moderate. Conclusion It was seen that IL-10, IL-6, TNF-α, HMBG-1, and CPK levels evaluated at the CCHF patients' time of admission to the clinic and SSI clinical score were found to be significantly related. It is clear that more studies with patients and groups of healthy volunteers are needed on this subject.
背景 本研究旨在探讨血清高迁移率族蛋白B1（HMGB1）、白细胞介素（IL）-6、IL-8、IL-1β、IL-10和肿瘤坏死因子α（TNF-α）水平对克里米亚-刚果出血热（CCHF）患者疾病严重程度和死亡率的影响。
材料与方法 本研究在土耳其共和国一家三级医院的重症监护病房（ICU）和感染病房进行前瞻性研究。纳入年龄18岁及以上诊断为CCHF的患者。
结果 我们的研究纳入了30例患者，其中83.3%为男性，平均年龄为51.6±14.35岁。患者最常见的临床表现为全身不适（90%）和肌痛（63.3%）。在我们的研究中，发现IL-1β水平为1173.6（783.0 - 1823.0）pg/mL，IL-6为69.9（56.8 - 133.1）pg/mL，IL-8为191.2（152.8 - 516.9）pg/mL，TNF-α为129.5（104.9 - 270.8），HMGB1为37.01（29.26 - 75.18），IL-10为190.1（四分位间距：147.8 - 387.8）pg/mL。患者的严重程度评分指数（SSI）中位数得分为2.5（1.8 - 5.5）。患者的SSI评分与血清IL-6（r = 0.464，p = 0.010）、TNF-α（r = 0.420，p = 0.021）和IL-10水平（r = 0.518，p = 0.003）之间存在中度相关性，与血清HMGB1之间存在弱相关性（r = 0.392，p = 0.032）。观察到SSI与肌酸磷酸激酶（CPK）水平之间的相关性为中度（r = 0.499，p = 0.036）。
结论 可见，在CCHF患者入院时评估的IL-10、IL-6、TNF-α、HMBG-1和CPK水平与SSI临床评分显著相关。显然，关于这个主题需要对患者和健康志愿者组进行更多研究。
