School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China.
Hebei Key Laboratory of Forensic Medicine, Shijiazhuang 050017, China.
Anal Methods. 2023 Mar 2;15(9):1168-1177. doi: 10.1039/d2ay01893d.
Methyl parathion (MP) is a widely used organophosphate insecticide that is extremely toxic due to its ability to irreversibly inhibit acetylcholinesterase in the body and persistently accumulate in the environment. Timely detection of MP can prevent harmful residue exposure to humans. Therefore, the development of fast, efficient electrochemical methods to detect trace MP has been highly beneficial for monitoring harmful residues in foods and environment to ensure food safety and ecological conservation. Herein, a novel hybrid metal-organic framework (MOF) nanocomposite composed of Pt nanoparticles (PtNPs), multi-walled carbon nanotubes (MWCNTs), and UiO-66-NH (PtNPs/UiO-66-NH/MWCNTs) was rationally designed and prepared by a facile two-step strategy for the sensitive determination of MP. The synergistic effects are illustrated in detail using XRD, XPS, FTIR, TEM, and SEM studies as well as electrochemical technologies such as CV, EIS, and DPV. In addition, the performance of the ternary nanocomposite for detecting MP was investigated by comparing it with the binary-component one. The results showed that the PtNPs/UiO-66-NH/MWCNT-based electrochemical sensor exhibited outstanding sensitivity of 21.9 μA μM cm, satisfactory low detection limit of 0.026 μM and wide linear range of 0.11-227.95 μM for MP analysis. Furthermore, the fabricated sensor delivered distinguished freedom from interferences, outstanding regeneration ability, and adequate recoveries for fresh foods and river water samples. In conclusion, the proposed PtNPs/UiO-66-NH/MWCNT-based sensor provides a potentially useful analytical tool for determining hazardous residues of OPs in foods and the environment.
甲基对硫磷 (MP) 是一种广泛使用的有机磷杀虫剂，由于其能够不可逆地抑制体内乙酰胆碱酯酶并在环境中持续积累，因此具有极高的毒性。及时检测 MP 可以防止有害残留暴露于人体。因此，开发快速、高效的电化学方法来检测痕量 MP 对于监测食品和环境中的有害残留以确保食品安全和生态保护具有重要意义。在此，通过简便的两步策略合理设计并制备了一种由 Pt 纳米粒子 (PtNPs)、多壁碳纳米管 (MWCNTs) 和 UiO-66-NH 组成的新型混合金属-有机骨架 (MOF) 纳米复合材料 (PtNPs/UiO-66-NH/MWCNTs)，用于 MP 的灵敏测定。使用 XRD、XPS、FTIR、TEM 和 SEM 研究以及 CV、EIS 和 DPV 等电化学技术详细说明了协同作用。此外，通过将其与二元组分进行比较，研究了三元纳米复合材料检测 MP 的性能。结果表明，基于 PtNPs/UiO-66-NH/MWCNT 的电化学传感器表现出出色的灵敏度为 21.9 μA μM cm，令人满意的低检测限为 0.026 μM，以及用于 MP 分析的宽线性范围为 0.11-227.95 μM。此外，所制备的传感器在干扰物方面表现出出色的自由度、出色的再生能力以及对新鲜食品和河水样品的充分回收率。总之，所提出的基于 PtNPs/UiO-66-NH/MWCNT 的传感器为检测食品和环境中的 OP 危险残留提供了一种潜在有用的分析工具。
