School of medical laboratory science, College of health and medical sciences, Haramaya University, Harar, Ethiopia.
PLoS One. 2023 Feb 15;18(2):e0278829. doi: 10.1371/journal.pone.0278829. eCollection 2023.
Dental caries is defined as a dynamic diet microbial disease of teeth, which results in localized dissolution and destruction of the mineralized tissues of the teeth. Dental caries develops when there is a susceptible tooth exposed to pathogenic bacteria in the presence of substrate. Under these conditions, the bacteria metabolize substrate to form acid, which decalcifies teeth. Dental caries is among the top oral health problem in both developing and developed nations affecting around 20-50% of the population globally.
This study was conducted to assess the magnitude, associated factors, and antimicrobial susceptibility pattern of bacterial isolates among adult dental caries patients visiting Hiwot Fana specialized university hospital dental clinic from April 23 to-June 23, 2021.
An institutional-based cross-sectional study was conducted among 290 study participants. Convenient sampling techniques were used to select the study participants. Data was entered into Epi-info version 7.2.4.0 and exported to Statistical Package for the Social Sciences version 20 for analysis. The result was explained by using summary measures of texts, tables, and graphs after analysis by using bivariate and multivariate logistic regression. Statistical significance was defined at a p-value of less than 0.05.
The overall magnitude of bacteria among dental caries patients was 68.3%. S mutans 74(37.4%) and Lactobacillus spp 58(29.3%) were the most predominant isolated bacteria. Lack of teeth brushing (AOR: 2.8, 95% CI:1.6, 4.6), the habit of chewing khat always (AOR:4.8, 95%CI:2.10,8.80), the habit of chewing khat sometimes (AOR: 3.8: 95% CI: 2.520,9.48) and consumption of soft drinks (AOR: 1.9, 95% CI:1.2,3.1) were significantly associated with bacterial dental caries. Almost, all bacterial isolates were susceptible to ceftriaxone and ciprofloxacin compared to Amoxicillin, Azithromycin, chloramphenicol, clindamycin, doxycycline, erythromycin, gentamycin, penicillin, tetracycline, vancomycin and tobramycin.
Teeth brushing habit, consumption of soft drink and a habit of chewing khat affects dental health and they are associated with bacterial dental caries. Harari regional health bureau better to focus by giving health education to the community about dental caries based on identified associated factors with dental caries.
龋齿被定义为一种动态的饮食微生物牙齿疾病，导致牙齿的矿化组织局部溶解和破坏。当易感牙齿暴露于存在基质的致病细菌时，就会发生龋齿。在这些条件下，细菌代谢基质形成酸，从而使牙齿脱钙。龋齿是发展中国家和发达国家中最常见的口腔健康问题之一，全球约有 20-50%的人口受到影响。
本研究旨在评估 2021 年 4 月 23 日至 6 月 23 日期间，在 Hiwot Fana 专门大学医院牙科诊所就诊的成年龋齿患者中细菌分离株的严重程度、相关因素和抗菌药物敏感性模式。
采用基于机构的横断面研究，对 290 名研究参与者进行了研究。采用便利抽样技术选择研究参与者。数据输入 Epi-info 版本 7.2.4.0，并导出到统计软件包 20 进行分析。在使用双变量和多变量逻辑回归进行分析后，使用文本、表格和图形的汇总指标对结果进行解释。统计显著性定义为 p 值小于 0.05。
龋齿患者中细菌的总体发生率为 68.3%。S mutans 74（37.4%）和 Lactobacillus spp 58（29.3%）是最主要的分离菌。缺乏刷牙习惯（AOR：2.8，95%CI：1.6，4.6）、经常咀嚼恰特草（AOR：4.8，95%CI：2.10，8.80）、偶尔咀嚼恰特草（AOR：3.8：95%CI：2.520，9.48）和饮用软饮料（AOR：1.9，95%CI：1.2，3.1）与细菌性龋齿显著相关。与阿莫西林、阿奇霉素、氯霉素、克林霉素、强力霉素、红霉素、庆大霉素、青霉素、四环素、万古霉素和妥布霉素相比，几乎所有细菌分离株均对头孢曲松和环丙沙星敏感。
刷牙习惯、饮用软饮料和咀嚼恰特草的习惯会影响口腔健康，与细菌性龋齿有关。哈拉里地区卫生局最好根据与龋齿相关的因素，针对社区开展以龋齿为基础的健康教育。
