Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Pathol Res Pract. 2023 Mar;243:154373. doi: 10.1016/j.prp.2023.154373. Epub 2023 Feb 11.
In 2019, the World Health Organization (WHO) classification system updated the definition of mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs), previously known as mixed adenoneuroendocrine carcinomas (MANECs). The clinicopathological characteristics of this new definition remains to be clarified.
We analyzed the clinical data of 43 patients diagnosed with MiNENs in Wuhan Union Hospital from 2011 to 2020 according to the definition of MiNENs proposed in 2019.
Among the 43 patients with MiNENs, the top two most common sites were stomach and colon, and 69.8% were males. Nearly half (21/43) of the patients were diagnosed at TNM stage III, and about 53.5% (23/43) of patients were the neuroendocrine neoplasm dominant type. Among the non-neuroendocrine tumor components of 43 MiNENs patients, adenocarcinoma accounted for 95.3% (41/43) and squamous cell carcinoma accounted for 4.7% (2/43)；95.3% (41/43) of the neuroendocrine neoplasm components were neuroendocrine carcinoma (NEC) and 4.7% (2/43) were neuroendocrine tumor (NET). Approximately 60.5% (26/43) neuroendocrine components had a Ki-67 index ≥ 55%. In addition, we further compared the prognosis of different subtypes of the MiNENs based on the neuroendocrine neoplasm component and non-neuroendocrine neoplasm component, and the results showed that there was no significant difference in survival between different subtypes of MiNENs (P > 0.05).
MiNENs can exhibit diverse clinicopathological characteristics, and there is no significant difference in prognosis among MiNENs subtypes, indicating that the definition of MiNENs can well summarize the prognosis of this type of tumor.
2019 年，世界卫生组织（WHO）分类系统更新了混合神经内分泌-非神经内分泌肿瘤（MiNENs）的定义，此前称为混合性腺神经内分泌癌（MANECs）。这种新定义的临床病理特征仍有待阐明。
根据 2019 年提出的 MiNENs 定义，我们分析了 2011 年至 2020 年武汉协和医院诊断的 43 例 MiNENs 患者的临床资料。
在 43 例 MiNENs 患者中，最常见的两个部位是胃和结肠，男性占 69.8%。近一半（21/43）的患者诊断为 III 期 TNM，约 53.5%（23/43）的患者为神经内分泌肿瘤优势型。在 43 例 MiNENs 患者的非神经内分泌肿瘤成分中，腺癌占 95.3%（41/43），鳞状细胞癌占 4.7%（2/43）；神经内分泌肿瘤成分中 95.3%（41/43）为神经内分泌癌（NEC），4.7%（2/43）为神经内分泌肿瘤（NET）。约 60.5%（26/43）的神经内分泌成分 Ki-67 指数≥55%。此外，我们还进一步根据神经内分泌肿瘤成分和非神经内分泌肿瘤成分比较了 MiNENs 不同亚型的预后，结果显示 MiNENs 不同亚型的生存无显著差异（P＞0.05）。
MiNENs 可表现出不同的临床病理特征，MiNENs 各亚型的预后无显著差异，表明 MiNENs 的定义能很好地总结此类肿瘤的预后。
