Zheng Lingnan, Sun Lingqi, Ma Ji
Abdominal Oncology Ward, Division of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Department of Neurology, The Air Force Hospital of Western Theater Command, Chengdu, Sichuan, China.
Front Pharmacol. 2024 Feb 1;15:1295134. doi: 10.3389/fphar.2024.1295134. eCollection 2024.
Gastric mixed neuroendocrine-non-neuroendocrine tumor (MiNEN), a rare malignancy, currently has no standard treatment. Here, we report a patient with pathologically confirmed gastric MiNEN following radical surgery with rapid postoperative distant tumor recurrence. Immunofluorescence results suggested intensive lymphocyte infiltration in the tumor. The programmed death receptor ligand 1 (PD-L1) immunohistochemistry 22C3 pharmDx assay showed tumor proportion score was 5% and combined positive score was 10. After 6 cycles of treatment with etoposide and cisplatin in combination with toripalimab, efficacy was assessed as a complete response. Our report shows that for gastric MiNEN patients with high expression of PD-L1, chemotherapy combined with immune checkpoint inhibitors may achieve more significant efficacy.
胃混合性神经内分泌-非神经内分泌肿瘤（MiNEN）是一种罕见的恶性肿瘤，目前尚无标准治疗方案。在此，我们报告一例经病理确诊的胃MiNEN患者，该患者接受根治性手术后肿瘤迅速出现远处复发。免疫荧光结果提示肿瘤内有密集的淋巴细胞浸润。程序性死亡受体配体1（PD-L1）免疫组化22C3检测显示肿瘤比例分数为5%，联合阳性分数为10分。在接受依托泊苷、顺铂联合托瑞帕利单抗治疗6个周期后，疗效评估为完全缓解。我们的报告表明，对于PD-L1高表达的胃MiNEN患者，化疗联合免疫检查点抑制剂可能取得更显著的疗效。
