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用于切除桥小脑角面神经鞘瘤的束状保留技术

Fascicular-Sparing Technique for Resection of Cerebellopontine Angle Facial Nerve Schwannoma.

作者信息

Luzzi Sabino, Giotta Lucifero Alice, Rabski Jessica, Kadri Paulo A S, Al-Mefty Ossama

机构信息

Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Neurosurgery Unit, Department of Surgical Sciences, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

出版信息

World Neurosurg. 2023 May;173:4. doi: 10.1016/j.wneu.2023.02.042. Epub 2023 Feb 13.

Abstract

Surgery of cerebellopontine angle (CPA) facial nerve schwannoma (FNS) in patients with good facial nerve function is a challenge.Video 1 highlights the fascicular-sparing technique for resection of a CPA FNS. A 41-year-old male patient symptomatic with persistent headaches and tinnitus underwent a retrosigmoid approach for a right cystic CPA tumor, presumed vestibular schwannoma. Intraoperatively, the facial nerve was identified as fine multiple strands splayed around the perimetry of the tumor, which elicited a motor response at a low threshold stimulation. This finding led to the intraoperative diagnosis of FNS according to the reported criteria. Neuromonitoring-assisted fascicular-sparing resection technique was performed. It involved the gradual separation of the uninvolved nerve fibers using a fine-stimulating dissector at a threshold of 0.2 mA. Entry into the tumor was at a stimulation silent cyst. The tumor was debulked with preservation of the endoneurium and pulse irrigation hemostasis. A near-total resection was performed. The patient was discharged on the second postoperative day with a House-Brackman III facial nerve deficit. The deficit remained stable during the following annual follow-up visits. Resection of CPA FNS is indicated at the earliest sign of deficit. However, it might be encountered as masquerading at the surgery of an acoustic tumor. The fascicular-sparing technique is critical in avoiding injuries to the endoneurium during the resection and with the ability to preserve function. The sparing of endoneurium avoids collagenization, fibrosis, and ischemia of the nerve, which are known to be the pathologic substrate of worse functional outcomes.

摘要

对于面神经功能良好的桥小脑角(CPA)面神经鞘瘤(FNS)患者进行手术是一项挑战。视频1重点展示了切除CPA FNS的束状保留技术。一名41岁男性患者,有持续性头痛和耳鸣症状,接受了乙状窦后入路手术,以切除右侧囊性CPA肿瘤,初步诊断为前庭神经鞘瘤。术中,面神经被识别为围绕肿瘤周边散开的多束纤细神经束,在低阈值刺激下可引发运动反应。根据报告的标准,这一发现导致术中诊断为FNS。实施了神经监测辅助的束状保留切除技术。该技术包括使用阈值为0.2 mA的精细刺激解剖器逐渐分离未受累的神经纤维。在刺激无反应的囊肿处进入肿瘤。在保留神经内膜和脉冲冲洗止血的情况下对肿瘤进行了大部分切除。进行了近全切除。患者术后第二天出院,面神经功能为House-Brackman III级缺损。在随后的年度随访中,缺损保持稳定。一旦出现缺损的最早迹象,就应进行CPA FNS切除。然而,在听神经瘤手术中可能会遇到它伪装的情况。束状保留技术对于在切除过程中避免损伤神经内膜以及保留功能的能力至关重要。保留神经内膜可避免神经的胶原化、纤维化和缺血,而这些已知是导致功能预后较差的病理基础。

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