Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Int J Pharm. 2023 Mar 25;635:122705. doi: 10.1016/j.ijpharm.2023.122705. Epub 2023 Feb 13.
The exposome consists of several factors such as solar radiation and pollution, which can provoke skin damage and lead to premature skin aging. Thus, the use of multifunctional sunscreens is critical in order to prevent this damage. In addition, film formation is very important to reach the expected SPF. Within this context, the objective of the present study was to develop and evaluate the in vivo SPF, sensory, physico-mechanical, and film-forming properties of sunscreens containing a biopolymer from Tara and red algae. A clinical study of the film-forming effect and of skin hydration was performed by instrumental measurements and by biophysical and skin imaging techniques. The SPF of both formulations, with or without the biopolymer, was 45.6. This result was 10.09% higher than expected. higher than expected. However, the sunscreen added to the biopolymer showed better sensory and texture properties, significantly increased skin hydration and reduced transepidermal water loss. The film-forming property was observed by the analysis of Reflectance Confocal Microscopy images 2, 4, and 6 h after formulation application, and this result was more pronounced for the sunscreen added to the biopolymer. Thus, the film-forming property of the biopolymer was important for prolonging the skin barrier function due to film formation and to obtain more effective and multifunctional sunscreens that provide longer protection.
暴露组由多种因素组成，如太阳辐射和污染，这些因素会引发皮肤损伤，导致皮肤过早衰老。因此，为了防止这种损伤，使用具有多种功能的防晒霜至关重要。此外，成膜对于达到预期的 SPF 非常重要。在这种情况下，本研究的目的是开发和评估含有 Tara 生物聚合物和红藻的防晒霜的体内 SPF、感官、物理机械和成膜性能。通过仪器测量和生物物理及皮肤成像技术对成膜效果和皮肤水合作用进行了临床研究。两种配方（含或不含生物聚合物）的 SPF 均为 45.6。这一结果比预期高出 10.09%。然而，添加生物聚合物的防晒霜具有更好的感官和质地特性，可显著增加皮肤水分并减少经皮水分流失。通过在配方涂抹后 2、4 和 6 小时对反射共聚焦显微镜图像进行分析，观察到了成膜性能，对于添加了生物聚合物的防晒霜，这一结果更为明显。因此，生物聚合物的成膜性能对于延长皮肤屏障功能非常重要，因为它可以形成薄膜，并获得更有效和多功能的防晒霜，提供更长时间的保护。
