Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Japan.
Department of Radiology, Kurume University School of Medicine, Japan.
Intern Med. 2023 Oct 1;62(19):2877-2881. doi: 10.2169/internalmedicine.0574-22. Epub 2023 Feb 15.
Primary tracheal adenoid cystic carcinoma (TACC) is a rare malignancy without an established treatment. Central airway obstruction due to TACC often decreases the quality of life and has life-threatening consequences. A 19-year-old man with unresectable TACC and central airway obstruction suffered from progressive cough and dyspnea after exercise. Proton beam therapy (PBT) was selected as the preferred treatment over systemic anti-cancer chemotherapy for TACC. PBT led to complete remission of TACC and the almost complete disappearance of the respiratory symptoms without adverse events. PBT is a useful and safe treatment for unresectable primary TACC.
原发性气管腺样囊性癌（TACC）是一种罕见的恶性肿瘤，目前尚无既定的治疗方法。TACC 导致的中央气道阻塞常降低生活质量，并产生危及生命的后果。一位 19 岁的男性患有不可切除的 TACC 和中央气道阻塞，在运动后出现进行性咳嗽和呼吸困难。质子束治疗（PBT）被选为 TACC 的首选治疗方法，而不是全身性抗癌化疗。PBT 导致 TACC 完全缓解，几乎完全消除了呼吸症状，且无不良事件发生。PBT 是治疗不可切除的原发性 TACC 的一种有效且安全的方法。
