Azar T, Abdul-Karim F W, Tucker H M
Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, USA.
Laryngoscope. 1998 Sep;108(9):1297-300. doi: 10.1097/00005537-199809000-00006.
Primary tracheal tumors are rare, occurring in 0.2 per 100,000 persons per year. Adenoid cystic carcinoma (ACC) is the second most common histologic type of tracheal malignancy. Its clinical behavior is different from the other tracheal neoplasms and thus should be studied separately.
STUDY DESIGN/METHODS: Retrospective review of the medical records of six patients with tracheal ACC who were treated at University Hospitals of Cleveland between 1971 and 1996 and literature review.
RESULTS/CONCLUSION: Tracheal ACC is an indolent tumor that affects people at any age but has a peak incidence in the fifth decade. There is a nearly equal male-to-female ratio. Almost half of tracheal ACCs occur in the proximal trachea, accounting for the most common presenting symptoms: dyspnea, cough, and hoarseness. Because of the hoarseness, patients are often referred to an otolaryngologist. Complete resection provides the best chance for increased survival. Neutron beam radiotherapy holds promise for adjuvant therapy.
原发性气管肿瘤较为罕见，每年每10万人中发生0.2例。腺样囊性癌（ACC）是气管恶性肿瘤中第二常见的组织学类型。其临床行为与其他气管肿瘤不同，因此应单独进行研究。
研究设计/方法：回顾性分析1971年至1996年间在克利夫兰大学医院接受治疗的6例气管ACC患者的病历，并进行文献综述。
结果/结论：气管ACC是一种生长缓慢的肿瘤，可发生于任何年龄，但在50岁左右发病率最高。男女比例几乎相等。近一半的气管ACC发生在气管近端，导致最常见的症状：呼吸困难、咳嗽和声音嘶哑。由于声音嘶哑，患者常被转诊至耳鼻喉科医生处。完整切除提供了提高生存率的最佳机会。中子束放射治疗有望成为辅助治疗方法。
