Pharmaceutical Technology Department, Bordeaux University Hospital, Bordeaux, France.
Nuclear Medicine Department, Bordeaux University Hospital, Bordeaux, France.
Sci Rep. 2023 Feb 15;13(1):2721. doi: 10.1038/s41598-023-29923-z.
The sorption of drugs onto their contents is a known phenomenon that is difficult to analyse precisely. The purpose of this study was to present a non-invasive method for locating and quantifying sorption phenomena using radiopharmaceuticals. Radiopharmaceutical are medicines armed with a radionuclide enabling quantification and imaging using dedicated scanners. The sorption of nine different radiopharmaceuticals on 2- and 3-part syringes was investigated. These syringes were filled with the studied radiopharmaceutical solutions and stored immobile for 3 h. At different times ranging from 0 to 180 min, 10 µL were taken from the syringes and the radioactivity of these samples was determined by a gamma counter. 5 radiopharmaceuticals exhibited no significant sorption at any time point in both 2 and 3-parts syringes, but 4 radiopharmaceuticals exhibited sorption losses varying from 20 to 33% after 3 h contact with 3-part-syringes, but no sorption on 2-part syringes at any time point. [Tc]Tc-tetrofosmine Single Photon Emission Computed Tomography/Computed Tomography imaging indicated clearly that the interactions were located on the rubber plunger of the 3-part-syringes. The specific nature of radiopharmaceuticals allowed their use as an innovative method to quantify and localize drug sorption phenomena.
药物吸附到其内容物中是一种已知的现象，很难进行精确分析。本研究的目的是提出一种使用放射性药物定位和量化吸附现象的非侵入性方法。放射性药物是一种装有放射性核素的药物，可使用专用扫描仪进行定量和成像。研究了 9 种不同的放射性药物在 2 部分和 3 部分注射器上的吸附情况。这些注射器中装有研究用的放射性药物溶液，在 3 小时内保持不动。在 0 到 180 分钟的不同时间点，从注射器中取出 10 μL，并使用伽马计数器测定这些样品的放射性。在 2 部分和 3 部分注射器中，5 种放射性药物在任何时间点都没有明显的吸附，但在与 3 部分注射器接触 3 小时后，4 种放射性药物的吸附损失从 20%到 33%不等，但在任何时间点都没有在 2 部分注射器上发生吸附。[Tc]Tc-四氮茂单光子发射计算机断层扫描/计算机断层扫描成像清楚地表明，相互作用发生在 3 部分注射器的橡胶柱塞上。放射性药物的特殊性质允许它们被用作一种创新的方法来定量和定位药物吸附现象。
