Okuhata Katsuya, Monzen Hajime, Takai Go, Hosono Makoto
Department of Radiology, Kansai Electric Power Hospital, 2-1-7 Fukushima, Fukushima-ku, Osaka-shi, Osaka, 5530003, Japan.
Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, 377-2 Onohigashi, Osakasayama-shi, Osaka, 5898511, Japan.
Ann Nucl Med. 2025 Jun 23. doi: 10.1007/s12149-025-02064-1.
Lu-DOTATATE and Lu-PSMA-617 used as therapeutic radiopharmaceuticals are primarily excreted in urine and may cause relatively high levels of contamination in toilets and sink areas. This study aimed to comprehensively evaluate a novel fluorine-coated film as a practical solution for the management of Lu-DOTATATE contamination by (1) quantifying its decontamination efficiency, (2) assessing its effectiveness in clinical settings, and (3) identifying optimal applications in nuclear medicine facilities.
The developed hydrophobic films [fluorine-coated film (F-film) and fluorine-urethane resin-coated film (FU-film)] were prepared along with a commercial hydrophobic film (Aquaglide), stainless-steel plate, sink, and urine bag were used as the test materials. Contact angles were measured using the sessile-drop method. The relationship between the contact angle of each test material (excluding the sink) and the count reduction rate after applying Lu-DOTATATE (4.93 Bq/ml, 0.1 ml) was investigated. Each measurement was performed three times. To confirm the effectiveness in a clinical setting, the FU-film was applied to a toilet bowl, and the contamination after urination by patients who were administered Lu-DOTATATE was evaluated.
A strong positive correlation (r = 0.84, p = 0.001) was observed between the contact angle of the test material surface and the reduction rate of the count after wiping with a wet paper towel. Specifically, the counts of the F-film, FU-film, and Aquaglide, which had contact angles greater than 90°, decreased by 92.1%, 96.8%, and 97.4%, respectively, and the counts on the sink and the stainless-steel plate decreased by 71.9% and 69.2%, respectively. The count of the FU-film was 23.3% lower than that of the urine bag. The density of surface contamination of the FU-film after flushing was 62.2% lower than that of the toilet bowl and was lower than the background level.
The developed FU-film effectively prevents and reduces Lu-DOTATATE contamination, with a reduction rate as high as 96.8%. This is particularly useful for protecting areas where water flows directly, such as sinks and toilet bowls, and also for protecting other medical materials that may be contaminated with urine.
作为治疗性放射性药物的镥-奥曲肽和镥-PSMA-617主要经尿液排泄，可能会在马桶和水槽区域造成较高程度的污染。本研究旨在全面评估一种新型氟涂层薄膜，作为管理镥-奥曲肽污染的实用解决方案，具体包括：（1）量化其去污效率；（2）评估其在临床环境中的有效性；（3）确定在核医学设施中的最佳应用。
制备了所开发的疏水薄膜[氟涂层薄膜（F薄膜）和氟聚氨酯树脂涂层薄膜（FU薄膜）]，并使用一种商用疏水薄膜（Aquaglide）、不锈钢板、水槽和尿袋作为测试材料。采用静滴法测量接触角。研究了每种测试材料（不包括水槽）的接触角与涂抹镥-奥曲肽（4.93 Bq/ml，0.1 ml）后计数减少率之间的关系。每次测量重复进行三次。为确认在临床环境中的有效性，将FU薄膜应用于马桶，评估接受镥-奥曲肽治疗的患者排尿后的污染情况。
测试材料表面的接触角与用湿纸巾擦拭后计数的减少率之间观察到强正相关（r = 0.84，p = 0.001）。具体而言，接触角大于90°的F薄膜、FU薄膜和Aquaglide的计数分别减少了92.1%、96.8%和97.4%，水槽和不锈钢板上的计数分别减少了71.9%和69.2%。FU薄膜的计数比尿袋低23.3%。冲洗后FU薄膜的表面污染密度比马桶低62.2%，且低于背景水平。
所开发的FU薄膜能有效预防和减少镥-奥曲肽污染，减少率高达96.8%。这对于保护水槽和马桶等水直接流动的区域，以及保护其他可能被尿液污染的医疗材料特别有用。
