小鼠下丘脑对天然免疫某些方面的调控。
Hypothalamic control of certain aspects of natural immunity in the mouse.
作者信息
Belluardo N, Mudó G, Cella S, Santoni A, Forni G, Bindoni M
机构信息
Institute of Human Physiology, University of Catania, Italy.
出版信息
Immunology. 1987 Oct;62(2):321-7.
Electrothermocoagulation (ETC) of the individual nuclei of the median region of the hypothalamus (MH) in the C57BL/6 mouse leads to a significant reduction in the cytotoxic activity of natural killer cells (NK) and the number of large granular lymphocytes (LGL) compared with intact or sham-operated controls. This effect, however, is less than that observed after simultaneous destruction of all MH nuclei. By contrast, no significant change in NK activity was noted after ETC of the anterior (AH) or posterior (PH) regions. Diminution of NK activity due to nuclear MH destruction is not an outcome of the change in adenohypophysis secretion provoked by hypothalamic lesion. Natural cytotoxic activity was markedly increased after ETG located either in AH, or MH, or PH. These results indicate that NK- and NC-mediated immunity is governed by a control mechanism situated in the hypothalamus.
与完整或假手术对照组相比，对C57BL/6小鼠下丘脑正中区域（MH）的各个核团进行电热凝术（ETC）会导致自然杀伤细胞（NK）的细胞毒性活性和大颗粒淋巴细胞（LGL）数量显著减少。然而，这种效应小于同时破坏所有MH核团后观察到的效应。相比之下，对前部（AH）或后部（PH）区域进行ETC后，未观察到NK活性有显著变化。由于MH核团破坏导致的NK活性降低不是下丘脑损伤引起的腺垂体分泌变化的结果。位于AH、MH或PH的电热凝术（ETG）后，自然细胞毒性活性显著增加。这些结果表明，NK和NC介导的免疫受位于下丘脑的一种控制机制调节。
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