Santoni A, Cerruti Sola S, Giovarelli M, Martinetto P, Vietti D, Forni G
Nat Immun Cell Growth Regul. 1986;5(5):259-66.
Groups of BALB/C mice received a diet supplement of 0 (group C), 200 (group A 200), 500 (group A 500), and 1,000 (group A 1,000) IU retinol palmitate (RP)/mouse/day in drinking water for 450 days. At progressive time intervals, mice from each group were tested for natural killer (NK) activity and for the percentage of large granular lymphocytes (LGL) in the spleen. In groups A 200, A 500 and A 1,000, a dose-dependent increase in NK activity was evident 50 days after the beginning of RP supplementation and was accompanied by a parallel increase of LGL number in the spleen. In group A 1,000, the increase of spontaneous or Poly I:C-induced cytotoxicity persisted until day 160. By contrast, inhibition of Poly I:C-induced NK cytotoxicity was found in this group at day 450.
将BALB/C小鼠分为几组，分别给予0（C组）、200（A 200组）、500（A 500组）和1000（A 1000组）国际单位视黄醇棕榈酸酯（RP）/只/天的饮水饮食补充剂，持续450天。在不同的时间间隔，检测每组小鼠的自然杀伤（NK）活性以及脾脏中大颗粒淋巴细胞（LGL）的百分比。在A 200组、A 500组和A 1000组中，补充RP开始50天后，NK活性呈剂量依赖性增加，同时脾脏中LGL数量也相应增加。在A 1000组中，自发或聚肌胞苷酸（Poly I:C）诱导的细胞毒性增加持续到第160天。相比之下，在第450天时，该组中发现Poly I:C诱导的NK细胞毒性受到抑制。
