噬菌体在致病性弧菌进化中的作用及其在噬菌体治疗中的应用。
Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy.
机构信息
Stuart B. Levy Center for Integrated Management of Antimicrobial Resistance (Levy CIMAR), Tufts Medical Center and Tufts University, Boston, MA, USA.
Department of Molecular Biology and Microbiology, Tufts University, School of Medicine, Boston, MA, USA.
出版信息
Adv Exp Med Biol. 2023;1404:149-173. doi: 10.1007/978-3-031-22997-8_8.
Viruses of bacteria, i.e., bacteriophages (or phages for short), were discovered over a century ago and have played a major role as a model system for the establishment of the fields of microbial genetics and molecular biology. Despite the relative simplicity of phages, microbiologists are continually discovering new aspects of their biology including mechanisms for battling host defenses. In turn, novel mechanisms of host defense against phages are being discovered at a rapid clip. A deeper understanding of the arms race between bacteria and phages will continue to reveal novel molecular mechanisms and will be important for the rational design of phage-based prophylaxis and therapies to prevent and treat bacterial infections, respectively. Here we delve into the molecular interactions of Vibrio species and phages.
细菌病毒，即噬菌体（简称 phages），在一个多世纪前就被发现了，它们在建立微生物遗传学和分子生物学领域方面发挥了重要作用，是一个主要的模式系统。尽管噬菌体相对简单，但微生物学家不断发现它们生物学的新方面，包括与宿主防御作斗争的机制。反过来，宿主防御噬菌体的新机制也在迅速被发现。对细菌和噬菌体之间军备竞赛的更深入了解将继续揭示新的分子机制，并分别对基于噬菌体的预防和治疗细菌感染的合理设计具有重要意义。在这里，我们深入研究了弧菌属物种和噬菌体的分子相互作用。
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