Northeast Center for Vibrio Disease and Ecology, University of New Hampshire, Durham, New Hampshire, USA.
Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, New Hampshire, USA.
mBio. 2024 Jan 16;15(1):e0285123. doi: 10.1128/mbio.02851-23. Epub 2023 Dec 19.
An understanding of the processes that contribute to the emergence of pathogens from environmental reservoirs is critical as changing climate precipitates pathogen evolution and population expansion. Phylogeographic analysis of hosts combined with the analysis of their phage resolved ambiguities of diversification dynamics which preceded successful Atlantic invasion by the epidemiologically predominant ST36 lineage. It has been established experimentally that filamentous phage can limit host recombination, but here, we show that phage loss is linked to rapid bacterial host diversification during epidemic spread in natural ecosystems alluding to a potential role for ubiquitous inoviruses in the adaptability of pathogens. This work paves the way for functional analyses to define the contribution of inoviruses in the evolutionary dynamics of environmentally transmitted pathogens.
了解导致病原体从环境库中出现的过程至关重要，因为气候变化正在促使病原体进化和种群扩张。对宿主的系统地理学分析结合对其噬菌体的分析，解决了在流行病学上占主导地位的 ST36 谱系成功入侵大西洋之前的多样化动态的不确定性。实验已经证实丝状噬菌体可以限制宿主重组，但在这里，我们表明在自然生态系统中流行传播期间，噬菌体的丢失与细菌宿主的快速多样化有关，这暗示了普遍存在的内噬菌体在病原体的适应性方面可能发挥作用。这项工作为功能分析铺平了道路，以确定内噬菌体在环境传播病原体的进化动态中的贡献。
