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创伤弧菌,一种被低估的人畜共患病病原体。

Vibrio vulnificus, an Underestimated Zoonotic Pathogen.

机构信息

Departamento de Microbiología y Ecología, & Instituto Universitario de Biotecnologia i Biomedicina (BIOTECMED), Universitat de València, Burjassot, Valencia, Spain.

出版信息

Adv Exp Med Biol. 2023;1404:175-194. doi: 10.1007/978-3-031-22997-8_9.

Abstract

V. vulnificus, continues being an underestimated yet lethal zoonotic pathogen. In this chapter, we provide a comprehensive review of numerous aspects of the biology, epidemiology, and virulence mechanisms of this poorly understood pathogen. We will emphasize the widespread role of horizontal gene transfer in V. vulnificus specifically virulence plasmids and draw parallels from aquaculture farms to human health. By placing current findings in the context of climate change, we will also contend that fish farms act as evolutionary drivers that accelerate species evolution and the emergence of new virulent groups. Overall, we suggest that on-farm control measures should be adopted both to protect animals from Vibriosis, and also as a public health measure to prevent the emergence of new zoonotic groups.

摘要

创伤弧菌仍然是一种被低估但致命的人畜共患病病原体。在本章中,我们全面回顾了这种了解甚少的病原体的生物学、流行病学和毒力机制的多个方面。我们将强调水平基因转移在创伤弧菌特别是毒力质粒中的广泛作用,并从水产养殖农场到人类健康方面进行类比。通过将当前的发现置于气候变化的背景下,我们还认为鱼类养殖场是加速物种进化和新的毒力群体出现的进化驱动因素。总的来说,我们建议采取农场控制措施,既保护动物免受弧菌病的侵害,也作为预防新的人畜共患病群体出现的公共卫生措施。

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