Department of Microbiology and Ecology, Instituto Universitario de Biotecnología y Biomedicina BIOTECMED, Universidad de Valencia Campus Burjassot, Valencia, Spain.
Department of Medicine, Emek Medical Center, Clalit Health Services, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Afula, Israel.
J Clin Microbiol. 2021 Jan 21;59(2). doi: 10.1128/JCM.01763-20.
is a zoonotic pathogen that is spreading worldwide due to global warming. Lineage 3 (L3; formerly biotype 3) includes the strains of the species with the unique ability to cause fish farm-linked outbreaks of septicemia. The L3 strains emerged recently and are particularly virulent and difficult to identify. Here, we describe a newly developed PCR method based on a comparative genomic study useful for both rapid identification and epidemiological studies of this interesting emerging group. The comparative genomic analysis also revealed the presence of a genetic duplication in the L3 strains that could be related to the unique ability of this lineage to produce septicemia outbreaks.
是一种人畜共患病病原体，由于全球变暖正在在全球范围内传播。第 3 谱系（L3；以前的生物型 3）包括具有引起鱼类养殖场相关败血性败血症暴发的独特能力的物种菌株。L3 菌株最近出现，特别具有毒性且难以识别。在这里，我们描述了一种基于比较基因组研究的新开发的 PCR 方法，该方法既有助于快速鉴定，也有助于对这一有趣的新兴群体进行流行病学研究。比较基因组分析还揭示了 L3 菌株中存在基因重复，这可能与该谱系产生败血性败血症暴发的独特能力有关。
