Department of Biological Sciences, University of Delaware, Newark, DE, USA.
Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA.
Adv Exp Med Biol. 2023;1404:195-211. doi: 10.1007/978-3-031-22997-8_10.
Vibrio cholerae, the agent of cholera, is a natural inhabitant of aquatic environments. Over the past decades, the importance of specific nutrients and micronutrients in the environmental survival, host colonization, and pathogenesis of this species has become increasingly clear. For instance, V. cholerae has evolved ingenious mechanisms that allow the bacterium to colonize and establish a niche in the intestine of human hosts, where it competes with commensals (gut microbiota) and other pathogenic bacteria for available nutrients. Here, we discuss the carbon and energy sources utilized by V. cholerae and what is known about the role of nutrition in V. cholerae colonization. We examine how nutritional signals affect virulence gene regulation and how interactions with intestinal commensal species can affect intestinal colonization.
霍乱弧菌是霍乱的病原体，是水生环境的天然居民。在过去的几十年中，特定营养物质和微量元素在该物种的环境生存、宿主定植和发病机制中的重要性变得越来越明显。例如，霍乱弧菌已经进化出巧妙的机制，使细菌能够在人类宿主的肠道中定植并建立小生境，在那里它与共生菌（肠道微生物群）和其他致病菌争夺可用的营养物质。在这里，我们讨论霍乱弧菌利用的碳源和能源，以及营养在霍乱弧菌定植中的作用。我们研究了营养信号如何影响毒力基因的调节，以及与肠道共生物种的相互作用如何影响肠道定植。
