Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA.
Department of Neurology, Harvard Medical School, Boston, MA.
J Speech Lang Hear Res. 2023 Mar 7;66(3):791-803. doi: 10.1044/2022_JSLHR-22-00436. Epub 2023 Feb 16.
The purpose of this study was to investigate comorbidity prevalence and patterns in childhood apraxia of speech (CAS) and their relationship to severity.
In this retroactive cross-sectional study, medical records for 375 children with CAS ( = 4;9 [years;months], = 2;9) were examined for comorbid conditions. The total number of comorbid conditions and the number of communication-related comorbidities were regressed on CAS severity as rated by speech-language pathologists during diagnosis. The relationship between CAS severity and the presence of four common comorbid conditions was also examined using ordinal or multinomial regressions.
Overall, 83 children were classified with mild CAS; 35, with moderate CAS; and 257, with severe CAS. Only one child had no comorbidities. The average number of comorbid conditions was 8.4 ( = 3.4), and the average number of communication-related comorbidities was 5.6 ( = 2.2). Over 95% of children had comorbid expressive language impairment. Children with comorbid intellectual disability (78.1%), receptive language impairment (72.5%), and nonspeech apraxia (37.3%; including limb, nonspeech oromotor, and oculomotor apraxia) were significantly more likely to have severe CAS than children without these comorbidities. However, children with comorbid autism spectrum disorder (33.6%) were no more likely to have severe CAS than children without autism.
Comorbidity appears to be the rule, rather than the exception, for children with CAS. Comorbid intellectual disability, receptive language impairment, and nonspeech apraxia confer additional risk for more severe forms of CAS. Findings are limited by being from a convenience sample of participants but inform future models of comorbidity.
本研究旨在调查儿童运动性言语失用症(CAS)的共病患病率和模式及其与严重程度的关系。
在这项回顾性横断面研究中,检查了 375 名 CAS 儿童(n=4;9[年;月],M=2;9)的病历,以确定共病情况。将言语语言病理学家在诊断期间评定的 CAS 严重程度与共病数量和与交流相关的共病数量进行回归分析。还使用有序或多项回归分析,检查 CAS 严重程度与四种常见共病的存在之间的关系。
共有 83 名儿童被归类为轻度 CAS,35 名儿童为中度 CAS,257 名儿童为重度 CAS。仅有一名儿童没有共病。共病数量的平均值为 8.4(SD=3.4),与交流相关的共病数量的平均值为 5.6(SD=2.2)。超过 95%的儿童存在表达性语言障碍共病。与没有这些共病的儿童相比,存在智力障碍(78.1%)、接受性语言障碍(72.5%)和非言语运动失用(37.3%;包括肢体、非言语口运动和眼运动失用)的儿童更有可能患有重度 CAS。然而,存在自闭症谱系障碍(33.6%)的儿童与没有自闭症的儿童相比,更不可能患有重度 CAS。
共病似乎是儿童 CAS 的普遍现象,而非例外。智力障碍、接受性语言障碍和非言语运动失用的共病为更严重形式的 CAS 带来了额外的风险。这些发现受到参与者的便利性样本的限制,但为未来的共病模型提供了信息。