Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America.
Maternal, Newborn and Child Health Specialist, UNICEF, NYHQ, New York, New York, United States of America.
PLoS One. 2023 Feb 16;18(2):e0281764. doi: 10.1371/journal.pone.0281764. eCollection 2023.
In this study the authors examine the relationship between "zero-dose" communities and access to healthcare services. This was done by first ensuring the first dose of the Diphtheria Tetanus and Pertussis vaccine was a better measure of zero-dose communities than the measles-containing vaccine. Once ensured, it was used to examine the association with access to primary healthcare services for children and pregnant women in the Democratic Republic of Congo, Afghanistan, and Bangladesh. These services were divided into: a) unscheduled healthcare services such as birth assistance as well as seeking care and treatment for diarrheal diseases and cough/fever episodes and b) other scheduled health services such as antenatal care visits and vitamin A supplementation. Using recent Demographic Health Survey data (2014: Democratic Republic of Congo, 2015: Afghanistan, 2018: Bangladesh), data was analyzed via Chi Squared analysis or Fischer's Exact Test. If significant, a linear regression analysis was performed to examine if the association was linear. While the linear relationship observed between children who had received the first dose of the Diphtheria Tetanus and Pertussis vaccine (the reverse to zero-dose communities) and coverage of other vaccines was expected, the results of the regression analysis depicted an unexpected split in behavior. For scheduled and birth assistance health services, a linear relationship was generally observed. For unscheduled services associated with illness treatments, this was not the case. While it does not appear that the first dose of the Diphtheria Tetanus and Pertussis vaccine can be used to predict (at least in a linear manner) access to some primary (particularly illness treatment) healthcare services in emergency/ humanitarian settings, it can serve as an indirect measure of health services not associated with the treatment of childhood infections such as antenatal care, skilled birth assistance, and to a lesser degree even vitamin A supplementation.
在这项研究中,作者研究了“零剂量”社区与获得医疗保健服务之间的关系。作者首先确保白喉、破伤风和百日咳疫苗的第一剂比含麻疹疫苗更能衡量零剂量社区,然后利用它来检查在刚果民主共和国、阿富汗和孟加拉国,儿童和孕妇获得初级保健服务的情况。这些服务分为:a) 非计划性保健服务,如分娩协助,以及治疗腹泻病和咳嗽/发热疾病;b) 其他计划性保健服务,如产前护理就诊和维生素 A 补充。作者使用最近的人口健康调查数据(2014 年:刚果民主共和国,2015 年:阿富汗,2018 年:孟加拉国),通过卡方检验或 Fisher 精确检验分析数据。如果有显著差异,则进行线性回归分析,以检查关联是否呈线性。虽然观察到接受白喉、破伤风和百日咳疫苗第一剂(与零剂量社区相反)的儿童与其他疫苗覆盖率之间存在线性关系,但回归分析的结果描绘了一种意想不到的行为分裂。对于计划性和分娩协助保健服务,通常观察到线性关系。对于与疾病治疗相关的非计划性服务,情况并非如此。虽然白喉、破伤风和百日咳疫苗的第一剂似乎不能用于预测(至少以线性方式)紧急/人道主义环境中某些初级(特别是疾病治疗)保健服务的获得情况,但它可以作为与治疗儿童感染无关的保健服务的间接衡量标准,例如产前护理、熟练的分娩协助,以及在较小程度上甚至维生素 A 补充。