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Early-Life Dysbiosis and Th17 Asthma: Never Is Better than Late.

作者信息

Linden Dermot A, Einarsson Gisli G

机构信息

Wellcome Wolfson Institute for Experimental Medicine Queen's University Belfast Belfast, United Kingdom.

Halo Research Group Queen's University Belfast Belfast, United Kingdom.

出版信息

Am J Respir Cell Mol Biol. 2023 May;68(5):467-469. doi: 10.1165/rcmb.2023-0023ED.

DOI:10.1165/rcmb.2023-0023ED
PMID:36796087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10174171/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b326/10174171/ed2fcf995b95/rcmb.2023-0023EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b326/10174171/ed2fcf995b95/rcmb.2023-0023EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b326/10174171/ed2fcf995b95/rcmb.2023-0023EDf1.jpg

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Early-Life Dysbiosis and Th17 Asthma: Never Is Better than Late.早期生命菌群失调与Th17型哮喘：早发不如晚发。
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Airway microbial dysbiosis in asthmatic patients: A target for prevention and treatment?哮喘患者的气道微生物失调：预防和治疗的新靶点？
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本文引用的文献

1
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice.延迟的微生物成熟可持久加重小鼠 Th17 驱动型哮喘。
Am J Respir Cell Mol Biol. 2023 May;68(5):498-510. doi: 10.1165/rcmb.2022-0367OC.
2
Intestinal Microbiota-derived Propionic Acid Protects against Zinc Oxide Nanoparticle-induced Lung Injury.肠道微生物衍生的丙酸可预防氧化锌纳米颗粒引起的肺损伤。
Am J Respir Cell Mol Biol. 2022 Dec;67(6):680-694. doi: 10.1165/rcmb.2021-0515OC.
3
Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes.
2 低水平富集严重哮喘队列的加重特征和危险因素：评估哮喘加重表型的临床试验。
Am J Respir Crit Care Med. 2022 Sep 1;206(5):545-553. doi: 10.1164/rccm.202201-0129OC.
4
Association of infant antibiotic exposure and risk of childhood asthma: A meta-analysis.婴儿抗生素暴露与儿童哮喘风险的关联：一项荟萃分析。
World Allergy Organ J. 2021 Dec 6;14(11):100607. doi: 10.1016/j.waojou.2021.100607. eCollection 2021 Nov.
5
Oral administration of maternal vaginal microbes at birth to restore gut microbiome development in infants born by caesarean section: A pilot randomised placebo-controlled trial.出生时经口摄入母体阴道微生物以恢复剖宫产婴儿肠道微生物组发育：一项先导随机安慰剂对照试验。
EBioMedicine. 2021 Jul;69:103443. doi: 10.1016/j.ebiom.2021.103443. Epub 2021 Jun 27.
6
Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants.益生菌预防极早产儿或极低出生体重儿坏死性小肠结肠炎。
Cochrane Database Syst Rev. 2020 Oct 15;10(10):CD005496. doi: 10.1002/14651858.CD005496.pub5.
7
Microbes, metabolites, and the gut-lung axis.微生物、代谢物和肠-肺轴。
Mucosal Immunol. 2019 Jul;12(4):843-850. doi: 10.1038/s41385-019-0160-6. Epub 2019 Apr 11.
8
High levels of butyrate and propionate in early life are associated with protection against atopy.生命早期丁酸和丙酸水平较高与预防特应性有关。
Allergy. 2019 Apr;74(4):799-809. doi: 10.1111/all.13660. Epub 2018 Nov 25.
9
Early-life antibiotics attenuate regulatory T cell generation and increase the severity of murine house dust mite-induced asthma.早期使用抗生素会削弱调节性 T 细胞的生成，增加鼠类屋尘螨诱导的哮喘的严重程度。
Pediatr Res. 2018 Sep;84(3):426-434. doi: 10.1038/s41390-018-0031-y. Epub 2018 Jul 2.
10
Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation.高风险哮喘婴儿的肠道微生物群发育延迟可通过补充乳酸菌暂时得到改善。
Nat Commun. 2018 Feb 16;9(1):707. doi: 10.1038/s41467-018-03157-4.