Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa; Center for Brain Circuit Therapeutics, Brigham & Women's Hospital, Boston, Massachusetts; Department of Neurology, Harvard Medical School, Boston, Massachusetts.
Center for Brain Circuit Therapeutics, Brigham & Women's Hospital, Boston, Massachusetts; Department of Neurology, Harvard Medical School, Boston, Massachusetts; Center for the Study of World Religions, Harvard Divinity School, Cambridge, Massachusetts.
Biol Psychiatry. 2023 Oct 15;94(8):640-649. doi: 10.1016/j.biopsych.2023.02.007. Epub 2023 Feb 14.
Emotion regulation has been linked to specific brain networks based on functional neuroimaging, but networks causally involved in emotion regulation remain unknown.
We studied patients with focal brain damage (N = 167) who completed the managing emotion subscale of the Mayer-Salovey-Caruso Emotional Intelligence Test, a measure of emotion regulation. First, we tested whether patients with lesions to an a priori network derived from functional neuroimaging showed impaired emotion regulation. Next, we leveraged lesion network mapping to derive a de novo brain network for emotion regulation. Finally, we used an independent lesion database (N = 629) to test whether damage to this lesion-derived network would increase the risk of neuropsychiatric conditions associated with emotion regulation impairment.
First, patients with lesions intersecting the a priori emotion regulation network derived from functional neuroimaging showed impairments in the managing emotion subscale of the Mayer-Salovey-Caruso Emotional Intelligence Test. Next, our de novo brain network for emotion regulation derived from lesion data was defined by functional connectivity to the left ventrolateral prefrontal cortex. Finally, in the independent database, lesions associated with mania, criminality, and depression intersected this de novo brain network more than lesions associated with other disorders.
The findings suggest that emotion regulation maps to a connected brain network centered on the left ventrolateral prefrontal cortex. Lesion damage to part of this network is associated with reported difficulties in managing emotions and is related to increased likelihood of having one of several neuropsychiatric disorders.
基于功能神经影像学，情绪调节与特定的大脑网络有关，但因果关系上涉及情绪调节的网络仍不清楚。
我们研究了 167 名有局灶性脑损伤的患者，他们完成了 Mayer-Salovey-Caruso 情绪智力测验的情绪管理子量表，这是一种情绪调节的测量方法。首先，我们测试了预先从功能神经影像学中得出的网络中出现病变的患者是否表现出情绪调节受损。其次，我们利用病变网络映射得出一个新的情绪调节脑网络。最后，我们使用一个独立的病变数据库（N=629）来测试损伤这个病变衍生网络是否会增加与情绪调节受损相关的神经精神疾病的风险。
首先，与功能神经影像学得出的预先存在的情绪调节网络有病变的患者，在 Mayer-Salovey-Caruso 情绪智力测验的情绪管理子量表上表现出了受损。其次，我们从病变数据中得出的情绪调节的新大脑网络，其定义是与左腹外侧前额叶的功能连接。最后，在独立的数据库中，与躁狂症、犯罪行为和抑郁症相关的病变与其他病变相比，更与这个新的大脑网络相交。
这些发现表明，情绪调节映射到一个以左腹外侧前额叶为中心的连接大脑网络。该网络的一部分受损与报告的情绪管理困难有关，与几种神经精神疾病的发生几率增加有关。
