Alcalá-Rivera N, Díez-Manglano J
Servicio de Medicina Interna, Hospital de Barbastro, Barbastro, Huesca, Spain.
Servicio de Medicina Interna, Hospital Royo Villanova, Zaragoza, Spain.
Rev Clin Esp (Barc). 2023 Mar;223(3):165-175. doi: 10.1016/j.rceng.2023.02.003. Epub 2023 Feb 14.
Studies on sexuality in patients with chronic obstructive pulmonary disease (COPD) are scarce and have yielded conflicting results. Our aim was to determine the prevalence of erectile dysfunction (ED) and associated factors in patients with COPD.
Articles with data on ED prevalence in patients diagnosed with COPD through spirometry were searched for in the PubMed, Embase, Cochrane Library, and Virtual Health Library databases from the year of their creation until January 31, 2021. The prevalence of ED was assessed with a weighted mean of the studies. A meta-analysis was performed using the Peto fixed-effect model to evaluate the association of COPD with ED.
Fifteen studies were ultimately included. The weighted prevalence of ED was 74.6%. A meta-analysis with four studies and 519 individuals showed an association of COPD with ED (estimated weighted odds ratio 2.89, 95% CI 1.93-4.32, p<0.001), with a non-negligible degree of heterogeneity (I 57%). In the systematic review, age, smoking, degree of obstruction, oxygen saturation, and previous health status were associated with a higher prevalence of ED.
ED is common in patients with COPD and its prevalence is higher than in the general population.
关于慢性阻塞性肺疾病（COPD）患者性功能的研究较少，且结果相互矛盾。我们的目的是确定COPD患者勃起功能障碍（ED）的患病率及相关因素。
在PubMed、Embase、Cochrane图书馆和虚拟健康图书馆数据库中，检索从创建年份至2021年1月31日通过肺活量测定诊断为COPD的患者中ED患病率的数据文章。用研究的加权平均值评估ED的患病率。采用Peto固定效应模型进行荟萃分析，以评估COPD与ED的关联。
最终纳入15项研究。ED的加权患病率为74.6%。对4项研究和519名个体进行的荟萃分析显示COPD与ED有关联（估计加权比值比为2.89，95%置信区间为1.93 - 4.32，p<0.001），异质性程度不可忽略（I² = 57%）。在系统评价中，年龄、吸烟、阻塞程度、血氧饱和度和既往健康状况与ED的较高患病率相关。
ED在COPD患者中很常见，其患病率高于一般人群。
