Department of Urology & Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Int J Impot Res. 2020 Mar;32(2):159-166. doi: 10.1038/s41443-019-0165-4. Epub 2019 Jul 1.
Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Mounting evidence shows that male patients with COPD have an increased risk of developing erectile dysfunction (ED). The aim of this meta-analysis was to assess the relationship between COPD and the risk of ED. To identify relevant studies, the PubMed, Cochrane Library and Embase databases, Chinese Biomedical Literature (CBM), China National Knowledge Infrastructure (CNKI) were systematically searched up to September 2018. Relative risks (RR) and corresponding 95% confidence intervals (CI) were used to estimate the strength of association between COPD and the risk of ED by using random-effects models. Finally, four studies (three cross-sectional, one cohort study) involving 58,307 participants were included. Synthesis results demonstrated that patients with COPD was not significantly associated with an increased overall prevalence of ED (RR = 1.31, 95% CI: 0.95-1.81, P = 0.099) compared to the healthy controls. However, the subgroup analyses showed that the prevalence of moderate ED (RR = 2.44, 95% CI: 1.29-4.59, P = 0.006) and severe ED (RR = 2.77, 95% CI: 1.57-4.94, P = 0.001) were significantly higher in patients with COPD. Evidence from this meta-analysis revealed that patients with COPD had a significantly increased susceptibility to moderate and severe ED, which should remind both clinicians and patients to be aware of the potential hazardous effect of COPD for developing ED.
慢性阻塞性肺疾病（COPD）是一种常见的慢性疾病。越来越多的证据表明，COPD 男性患者发生勃起功能障碍（ED）的风险增加。本荟萃分析的目的是评估 COPD 与 ED 风险之间的关系。为了确定相关研究，系统地检索了 PubMed、Cochrane 图书馆和 Embase 数据库、中国生物医学文献（CBM）、中国国家知识基础设施（CNKI），检索时间截至 2018 年 9 月。使用随机效应模型，通过相对风险（RR）和相应的 95％置信区间（CI）来评估 COPD 与 ED 风险之间的关联强度。最终，纳入了四项研究（三项横断面研究，一项队列研究），共涉及 58307 名参与者。综合结果表明，与健康对照组相比，COPD 患者的 ED 总体患病率无显著升高（RR=1.31，95％CI：0.95-1.81，P=0.099）。但是，亚组分析显示，COPD 患者中度 ED（RR=2.44，95％CI：1.29-4.59，P=0.006）和重度 ED（RR=2.77，95％CI：1.57-4.94，P=0.001）的患病率显著升高。这项荟萃分析的证据表明，COPD 患者发生中度和重度 ED 的易感性显著增加，这应提醒临床医生和患者注意 COPD 对 ED 发展的潜在危害作用。
