Manning S C, Beste D, McBride T, Goldberg A
Department of Otolaryngology, University of Texas Health Science Center, Dallas 75235.
Int J Pediatr Otorhinolaryngol. 1987 Oct;13(3):237-44. doi: 10.1016/0165-5876(87)90104-2.
Preoperative coagulation studies are commonly employed in order to try to identify the 2-4% of all patients undergoing tonsillectomy/adenoidectomy surgery who experience hemorrhagic complications. In an atmosphere of increasing cost consciousness, evaluation of the efficacy of screening tests is warranted. The records of 994 out of 1050 patients consecutively scheduled for tonsillectomy, adenoidectomy or T&A over a 2.5-year period were retrospectively reviewed in order to determine the usefulness of partial thromboplastin (PTT) and prothrombin time (PT) screening in predicting surgical and postsurgical bleeding. For patients with no history or clinical signs indicating possible bleeding disorder, preoperative PT and PTT failed to predict bleeding as an outcome. Also no patients were identified in this series to have previously undiagnosed coagulopathies on the basis of screening PT/PTT. The purpose of any screening test is to identify disease early enough for therapeutic intervention to be effective. Although preoperative PT/PTT will occasionally identify an unsuspected von Willebrand's or other coagulopathy, the prevalence of bleeding disorders in patients with negative history and examination is low enough that PT/PTT has essentially a zero predictive value for surgical bleeding. Screening PT/PTT should therefore be reserved for patients with known or suspected coagulopathies.
术前凝血功能检查通常用于试图识别在所有接受扁桃体切除术/腺样体切除术的患者中,那2%-4%会出现出血并发症的患者。在成本意识日益增强的环境下,对筛查试验的有效性进行评估是有必要的。回顾性分析了在2.5年期间连续安排进行扁桃体切除术、腺样体切除术或扁桃体腺样体切除术的1050例患者中的994例患者的记录,以确定部分凝血活酶时间(PTT)和凝血酶原时间(PT)筛查在预测手术中和术后出血方面的有用性。对于没有出血性疾病病史或临床体征的患者,术前PT和PTT无法预测出血这一结果。在该系列中,也没有患者基于PT/PTT筛查被确定患有先前未诊断出的凝血病。任何筛查试验的目的都是尽早识别疾病,以便治疗干预有效。虽然术前PT/PTT偶尔会识别出未被怀疑的血管性血友病或其他凝血病,但病史和检查结果为阴性的患者中出血性疾病的患病率足够低,以至于PT/PTT对手术出血的预测价值基本为零。因此,PT/PTT筛查应仅用于已知或疑似凝血病的患者。