Tolomelli B, Marchi Marchetti M, Laffi R, Marchetti M
Istituti di Chimica Biologica, Facolta' di Medicina e Chirurgia, Università di Bologna, Italy.
Int J Vitam Nutr Res. 1987;57(3):285-7.
To investigate the influence of folate deficiency on the addition process of glutamyl unit to folylpolyglutamates, liver folylpolyglutamate synthetase was studied. The enzyme activity appears slightly decreased in deficient liver as compared with control. This decline might be more evident in the hepatic cell owing to the lesser availability of reduced forms, preferred substrates of the enzyme.
为研究叶酸缺乏对谷氨酰基单元添加到叶酰聚谷氨酸过程的影响，对肝脏叶酰聚谷氨酸合成酶进行了研究。与对照组相比，缺乏组肝脏中的酶活性略有下降。由于该酶的首选底物还原形式的可用性较低，这种下降在肝细胞中可能更明显。
