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利用啮齿动物中的微生物暴露来模拟人类免疫反应。

Modelling human immune responses using microbial exposures in rodents.

机构信息

Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Nat Microbiol. 2023 Mar;8(3):363-366. doi: 10.1038/s41564-023-01334-w.

DOI:10.1038/s41564-023-01334-w
PMID:36797488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9992131/
Abstract

The extent and diversity of exposures to microbial stimuli have a crucial role in regulating the capacity of a host to mount an immune response to a challenge, such as vaccination, making exposure history an important factor to optimize in rodent models.

摘要

暴露于微生物刺激物的程度和多样性在调节宿主对挑战（如接种疫苗）产生免疫反应的能力方面起着至关重要的作用，这使得暴露史成为优化啮齿动物模型的一个重要因素。

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