Schmiedl U, Moseley M E, Sievers R, Ogan M D, Chew W M, Engeseth H, Finkbeiner W E, Lipton M J, Brasch R C
Contrast Media Laboratory, University of California School of Medicine, San Francisco.
Invest Radiol. 1987 Sep;22(9):713-21. doi: 10.1097/00004424-198709000-00004.
Magnetic resonance (MR) contrast enhancement of acute myocardial infarction was studied in rats using albumin-(Gd-DTPA), a paramagnetic macromolecule with prolonged intravascular retention after intravenous injection. Histologic examination and distribution measurements of radiolabeled microspheres confirmed induction of regional myocardial infarction after ligation of the left coronary artery. ECG-gated spin-echo images at 2.0 Tesla, employing short, T1-weighted pulse sequence settings, demonstrated time-persistent and significant (P less than .05) enhancement of normal myocardium (66%) and an even greater enhancement of the infarcted area (100%), for as long as 60 minutes after injection of 160 mg/kg albumin-(Gd-DTPA). The contrast difference between normal and infarcted myocardium was increased significantly (P less than .05) after administration of albumin-(Gd-DTPA). The prolonged enhancing effects of albumin-(Gd-DTPA) on MR images are useful for evaluating regional differences in blood volume and capillary integrity between normal and infarcted myocardium.
利用白蛋白-（钆-二乙三胺五乙酸）对大鼠急性心肌梗死的磁共振（MR）对比增强进行了研究，白蛋白-（钆-二乙三胺五乙酸）是一种静脉注射后在血管内滞留时间延长的顺磁性大分子。放射性标记微球的组织学检查和分布测量证实了左冠状动脉结扎后局部心肌梗死的诱发。在2.0特斯拉下采用短的T1加权脉冲序列设置的心电图门控自旋回波图像显示，在注射160mg/kg白蛋白-（钆-二乙三胺五乙酸）后长达60分钟内，正常心肌（66%）出现持续且显著（P小于0.05）的增强，梗死区域的增强更为明显（100%）。给予白蛋白-（钆-二乙三胺五乙酸）后，正常心肌与梗死心肌之间的对比差异显著增加（P小于0.05）。白蛋白-（钆-二乙三胺五乙酸）对MR图像的延长增强作用有助于评估正常心肌与梗死心肌之间血容量和毛细血管完整性的区域差异。
