Luo Minghao, Luo Suxin, Xue Yuzhou, Chang Qing, Yang Hui, Dong Wenyu, Zhang Ting, Cao Shuyuan
The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing, China.
Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
iScience. 2023 Jan 14;26(2):105990. doi: 10.1016/j.isci.2023.105990. eCollection 2023 Feb 17.
To determine the effect of aerobic exercise in different intensities on renal injury and epithelial-mesenchymal transformation (EMT) in the kidney of spontaneously hypertensive rats (SHR) and explore possible mechanisms, we subjected SHR to different levels of 14-week aerobic treadmill training. We tested the effects of aerobic exercise on irisin level, renal function, and EMT modulators in the kidney. We also treated angiotensin II-induced HK-2 cells with irisin and tested the changes in EMT levels. The data showed low and moderate aerobic exercise improved renal function and inhibited EMT through promoting irisin expression in SHR. However, high-intensity exercise training had no effect on renal injury and EMT in SHR but did significantly activate STAT3 phosphorylation in the kidney. These results clarify the mechanisms of exercise in improving hypertension-related renal injury and suggest that irisin might be a therapeutic target for patients with kidney injury.
为了确定不同强度有氧运动对自发性高血压大鼠（SHR）肾脏肾损伤和上皮-间质转化（EMT）的影响，并探索可能的机制，我们对SHR进行了为期14周的不同水平的有氧跑步机训练。我们测试了有氧运动对鸢尾素水平、肾功能和肾脏EMT调节因子的影响。我们还用鸢尾素处理了血管紧张素II诱导的HK-2细胞，并测试了EMT水平的变化。数据显示，低强度和中等强度的有氧运动可改善SHR的肾功能，并通过促进鸢尾素表达来抑制EMT。然而，高强度运动训练对SHR的肾损伤和EMT没有影响，但确实显著激活了肾脏中的STAT3磷酸化。这些结果阐明了运动改善高血压相关肾损伤的机制，并表明鸢尾素可能是肾损伤患者的治疗靶点。
