Graduate School, Wuhan Sports University, Wuhan, 430079, China.
College of Sports Medicine, Wuhan Sports University, Wuhan, 430079, China.
Curr Vasc Pharmacol. 2024;22(5):316-334. doi: 10.2174/0115701611285736240516101803.
Exercise is an effective measure for preventing and treating cardiovascular diseases, although the exact molecular mechanism remains unknown. Previous studies have shown that both irisin and exosomes can improve the course of cardiovascular disease independently. Therefore, it is speculated that the cardiovascular protective effect of exercise is also related to its ability to regulate the concentrations of irisin and exosomes in the circulatory system. In this review, the potential synergistic interactions between irisin and exosomes are examined, as well as the underlying mechanisms including the AMPK/PI3K/AKT pathway, the TGFβ1/Smad2/3 pathway, the PI3K/AKT/VEGF pathway, and the PTEN/PINK1/Parkin pathway are examined. This paper provides evidence to propose that exercise promotes the release of exosomes enriched with irisin, miR-486-5p and miR-342-5p from skeletal muscles, which results in the activation protective networks in the cardiovascular system. Moreover, the potential synergistic effect in exosomal cargo can provide new ideas for clinical research of exercise mimics.
运动是预防和治疗心血管疾病的有效措施，尽管其确切的分子机制尚不清楚。先前的研究表明，鸢尾素和外泌体都可以独立改善心血管疾病的进程。因此，人们推测运动对心血管的保护作用也与其调节循环系统中鸢尾素和外泌体浓度的能力有关。在这篇综述中，研究了鸢尾素和外泌体之间的潜在协同作用及其潜在机制，包括 AMPK/PI3K/AKT 通路、TGFβ1/Smad2/3 通路、PI3K/AKT/VEGF 通路和 PTEN/PINK1/Parkin 通路。本文提供了证据，提出运动促进富含鸢尾素、miR-486-5p 和 miR-342-5p 的外泌体从骨骼肌中释放，从而激活心血管系统中的保护网络。此外，外泌体货物中的潜在协同效应可为运动模拟的临床研究提供新的思路。
