Monica K, Rajeshkumar S, Ramasubramanian Abilasha, Ramani Pratibha, Sukumaran Gheena
Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Nano Biomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India.
J Adv Pharm Technol Res. 2022 Dec;13(Suppl 2):S369-S373. doi: 10.4103/japtr.japtr_515_22. Epub 2022 Dec 30.
Wound damage must be shielded from inflammatory responses caused by the external environment, while also receiving adequate moisture and promoting wound healing. , , and have proven effects on anti-inflammatory and antimicrobial effects as separate in various studies, but no studies have observed the synergistic effects of one herb on the other. The aim of the present study is to assess the anti-inflammatory and antimicrobial properties of karpooravalli, mint, and cinnamon formulation against wound pathogens for better healing of mouth ulcers through an study for further mouth paint preparation. Herbal extract is prepared using herbal plants karpooravalli, mint, and cinnamon. We studied the antimicrobial effects on , , and with ampicillin antibiotic disks as positive control and anti-inflammatory with control of diclofenac sodium. The antimicrobial activity of zone of inhibition increased with higher concentration of 100 μL against , , and at 20 mm, 18 mm, and 15 mm, respectively. The anti-inflammatory activity showed the highest percentage of inhibition using 50 μL with 91.5%; this reveals good anti-inflammatory activity by the synergistic action of the herbal formulation. The synergistic effect of the herbal formulation had a comparable anti-inflammatory activity as that of the standard. Hence, it can be employed in large-scale production and may be used for fabricating a natural product based on mouthwashes and mouth paints.
伤口损伤必须免受外部环境引起的炎症反应影响，同时还要保持足够的湿度并促进伤口愈合。在各种研究中，已分别证实[具体物质1]、[具体物质2]和[具体物质3]具有抗炎和抗菌作用，但尚无研究观察到一种草药对另一种草药的协同作用。本研究的目的是通过一项[具体研究类型]研究，评估卡普尔瓦利、薄荷和肉桂配方对伤口病原体的抗炎和抗菌特性，以促进口腔溃疡更好地愈合，以便进一步制备口腔涂料。使用卡普尔瓦利、薄荷和肉桂等草药植物制备草药提取物。我们以氨苄青霉素抗生素纸片作为阳性对照，研究了对[具体病原体1]、[具体病原体2]和[具体病原体3]的抗菌作用，并以双氯芬酸钠作为对照研究了其抗炎作用。抑菌圈的抗菌活性随着浓度升高而增加，100μL时对[具体病原体1]、[具体病原体2]和[具体病原体3]的抑菌圈分别为20mm、18mm和15mm。抗炎活性方面，50μL时抑制率最高，为91.5%；这表明该草药配方通过协同作用具有良好的抗炎活性。该草药配方的协同作用具有与标准品相当的抗炎活性。因此，它可用于大规模生产，并可用于制备基于漱口水和口腔涂料的天然产品。
