Agarwal Vatika, Maiti Subhabrata, Rajeshkumar S, Agarwal Sanjog
Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
J Adv Pharm Technol Res. 2022 Dec;13(Suppl 2):S485-S490. doi: 10.4103/japtr.japtr_215_22. Epub 2022 Dec 30.
This research was aimed at observing how antibacterial strength, colour stability, and compressive strength of chitosan modified PMMA compare to non modified PMMA [polymethyl methacrylate]. The study consisted of 2 groups - chitosan modified PMMA was the test group while unmodified PMMA was the control group. Twenty-four specimens were prepared for each group. Compressive strength was evaluated using the Universal testing machine. The antimicrobial action against streptococcus mutans and lactobacillus was evaluated using the disc diffusion method. A reflectance spectrophotometer was used to measure the baseline colour following the CIE Lab* scheme. Following these experiments, the specimens were submerged in coffee and distilled water solutions [ = 8] for 15 days each. Color stability was measured by comparing the coordinates obtained pre and post the ageing method. Independent t test used to examine data on colour change and compressive strength. [α = 0.05] It was observed that the incorporation of chitosan into polymethylmethacrylate increases its compressive strength. This was statistically significant [ = 0.00]. Improved colour stability was also observed [ = 0.000]. Antimicrobial action against streptococcus mutans and lactobacillus was seen in the chitosan modified group. Chitosan incorporation provides a promising improvement in the properties of the polymethylmethacrylate however further research with invivo studies are required to come to a conclusion.
本研究旨在观察壳聚糖改性聚甲基丙烯酸甲酯（PMMA）的抗菌强度、颜色稳定性和抗压强度与未改性聚甲基丙烯酸甲酯相比如何。该研究分为两组——壳聚糖改性PMMA为试验组，未改性PMMA为对照组。每组制备24个样本。使用万能试验机评估抗压强度。采用纸片扩散法评估对变形链球菌和乳酸杆菌的抗菌作用。使用反射分光光度计按照CIE Lab*方案测量基线颜色。在这些实验之后，将样本分别浸泡在咖啡和蒸馏水溶液（ = 8）中15天。通过比较老化前后获得的坐标来测量颜色稳定性。使用独立t检验来检验颜色变化和抗压强度的数据。[α = 0.05] 观察到壳聚糖掺入聚甲基丙烯酸甲酯中会增加其抗压强度。这具有统计学意义 [ = 0.00]。还观察到颜色稳定性有所改善 [ = 0.000]。壳聚糖改性组对变形链球菌和乳酸杆菌有抗菌作用。壳聚糖的掺入有望改善聚甲基丙烯酸甲酯的性能，然而需要进行进一步的体内研究才能得出结论。
