β-环糊精接枝透明质酸作为超分子多糖载体用于细胞靶向药物传递。
β-Cyclodextrin-grafted hyaluronic acid as a supramolecular polysaccharide carrier for cell-targeted drug delivery.
机构信息
Postdoctoral Innovation Practice Base, Department of Biological Applied Engineering, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China; State Key Laboratory Biocontrol, School of Marine Sciences, Sun Yat-sen University, Guangzhou 51027, China; Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Postdoctoral Innovation Practice Base, Department of Biological Applied Engineering, Shenzhen Key Laboratory of Fermentation, Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China; State Key Laboratory Biocontrol, School of Marine Sciences, Sun Yat-sen University, Guangzhou 51027, China.
出版信息
Int J Pharm. 2021 Jun 1;602:120602. doi: 10.1016/j.ijpharm.2021.120602. Epub 2021 Apr 20.
β-Cyclodextrin (β-CD) was grafted onto hyaluronic acid (HA) in a single step to generate a supramolecular biopolymer (HA-β-CD) that was explored for targeted drug delivery applications. Along with its excellent biocompatibility, the prepared HA-β-CD exhibits not only exceptionally high loading capacity for the model drugs doxorubicin and Rhodamine B through the formation of inclusion complexes with the β-CD component, but also the capability of targeted drug delivery to cancerous cells with a high level of expression of CD44 receptors, attributable to its HA component. The polymer can release the drug under slightly acidic conditions. With all its attributes, HA-β-CD may be a promising cancer-cell-targeting drug carrier.
β-环糊精（β-CD）被接枝到透明质酸（HA）上，一步生成超分子生物聚合物（HA-β-CD），用于靶向药物递送应用。除了其出色的生物相容性外，所制备的 HA-β-CD 不仅通过与β-CD 成分形成包合物而对模型药物阿霉素和罗丹明 B 表现出极高的载药能力，而且还具有靶向具有高水平 CD44 受体表达的癌细胞的药物递送能力，这归因于其 HA 成分。聚合物可以在微酸性条件下释放药物。HA-β-CD 具有所有这些特性，可能是一种有前途的癌细胞靶向药物载体。
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