Wei Wei, Qi Xiaoliang, Li Junjian, Zuo Gancheng, Sheng Wei, Zhang Jianfa, Dong Wei
Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing 210094, China.
ACS Biomater Sci Eng. 2016 Aug 8;2(8):1386-1394. doi: 10.1021/acsbiomaterials.6b00318. Epub 2016 Jul 15.
Poly(,-diethylacrylamide) is not only a thermosensitive polymer, but also a good hydrogen bond acceptor. Therefore, drugs with carboxyl groups can serve as hydrogen bond donors and form interactions with the tertiary amide groups in ,-diethylacrylamide. Herein, we report a novel drug delivery system for anionic drugs composed of poly(,-diethylacrylamide) and salecan. Salecan was used to improve the hydrophilicity and accelerate the responsive rate of this system. As expected, salecan-enriched hydrogels exhibited higher swelling ratios and were more sensitive to temperature. Moreover, scanning electron microscopy images showed that the hydrogels are superporous structures, with pore-sizes that increase with salecan concentration. The swelling ratios decreased continuously with the increase of temperature in the range 25-37 °C. MTT assay for cell viability and cell adhesion studies confirm the cell compatibility of the system. Delivery tests using diclofenac sodium, an anti-inflammatory drug, indicate that the thermosensitive property of this system is favorable for anionic drug delivery. Interestingly, the release rates of diclofenac sodium from the hydrogels were temperature dependent, with higher temperatures contributing toward faster release rate.
聚（N，N-二乙基丙烯酰胺）不仅是一种热敏聚合物，也是一种良好的氢键受体。因此，含羧基的药物可以作为氢键供体，并与N，N-二乙基丙烯酰胺中的叔酰胺基团形成相互作用。在此，我们报道了一种由聚（N，N-二乙基丙烯酰胺）和沙雷菌多糖组成的用于阴离子药物的新型药物递送系统。沙雷菌多糖用于改善该系统的亲水性并加快其响应速率。正如预期的那样，富含沙雷菌多糖的水凝胶表现出更高的溶胀率，并且对温度更敏感。此外，扫描电子显微镜图像显示水凝胶为超大孔结构，孔径随沙雷菌多糖浓度的增加而增大。在25-37°C范围内，溶胀率随温度升高而持续下降。用于细胞活力的MTT测定和细胞粘附研究证实了该系统的细胞相容性。使用抗炎药双氯芬酸钠进行的递送测试表明，该系统的热敏特性有利于阴离子药物的递送。有趣的是，双氯芬酸钠从水凝胶中的释放速率与温度有关，温度越高，释放速率越快。
